Dr. Rhodes must confront his past when he treats a close family friend who's been impaled by glass in a case that reunites him with his sister. Meanwhile, a musician must decide to undergo surgery that will save her life but could destroy her hearing.

A member of Firehouse 51 clings to life and takes a sudden turn for the worse as medical staffers race to give treatment. Meanwhile, Dr. Natalie Manning prepares for her pregnancy and members of Chicago P.D. probe the case of a woman pulled from a fire.

The crossover starts on Chicago Fire S04E10 The Beating Heart (I). It continues on Chicago P.D. S03E10 Now I'm God (III).

Chicago Med braces for an influx of trauma patients when a pre-dawn pileup finds the hospital in full scramble mode. As a result of the storm and emergencies, supplies become limited and Goodwin, Dr. Manning and Dr. Halstead must deal with making an impossible decision. Meanwhile, Dr. Choi handles a severely burned patient who has one final request and Dr. Charles deals with an agitated patient.

The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle.

The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).

Dr. Halstead rushes to rescue Dr. Manning after she is involved in a Medevac helicopter crash. The personal drama between Dr. Rhodes and Dr. Bekker boils over. Dr. Charles and Dr. Choi work to help a patient come to terms with their addiction. April helps Elsa deal with the loss of her first patient.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

The crossover starts on Chicago Fire S08E04 Infection (I). It continues on Chicago PD S07E04 Infection, Part III (III).

The team deals with the aftermath of a school bus crash. Dr. Charles worries Dr. Halstead is putting his medical license in jeopardy. Maggie helps a friend in need.

When a subway train goes off the tracks, Marcel volunteers to help the victims. Taylor and Halstead must decide if they’re willing to risk their jobs to save a patient. Asher and Archer clash over a pregnant patient.