The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle.

The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).