Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

The crossover starts on Chicago Fire S08E04 Infection (I). It continues on Chicago PD S07E04 Infection, Part III (III).

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Dylan and Will deal with a dishonest patient whose lupus is in remission. A wealthy donor makes inappropriate advances toward Stevie. Vanessa, Crockett and Charles try to convince a young woman to have life-saving surgery.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.