When Brian calls in sick for a day off from the FBI, the CIA abducts him from home to borrow his NZT-enhanced capabilities for a black ops mission. As the operation becomes increasingly dangerous, Brian finds himself without FBI support in a situation that's spiraling out of control.

After a list with the real identities of undercover bureau operatives leaks, Brian develops a personal connection with FBI Agent Lucy Church, a tenacious rule-breaker, when he helps her finish a field case before she's exposed. Also, Sands makes a surprising move to end Rebecca's investigation into Senator Morra.

When NZT floods the streets of New York City and threatens to become a national epidemic, the FBI partners with the DOJ in a city-wide manhunt to find the lab producing the drug. Also, Brian has trouble adjusting to his new reality when he lacks the resources to continue searching for Piper.

Following a stunning betrayal to their team, Brian and the FBI race to stop an NZT-enabled Sands and his associates from orchestrating an international incident. Also, Brian experiences devastating side effects when his NZT immunity starts to wear off.