A nightclub is used by vampires to trap unsuspecting guests and feed on them. Just as the feast is about to start, Blade arrives looking for the ancient vampire who long ago infected his mother - Deacon Frost. However, he gets company.

Sakomizu, a middle-aged police detective in Osaka, is troubled by a recent series of missing Southeast Asian women. After he meets up with Blade, they discover that the chief of police is helping to provide local vampires with human blood.

Blade invades Amaurot, the City of Vampires and headquarters of Existence, while cutting his way through anything that stands between him and now evolved Deacon Frost. Frost's monstrosities fight back, but Blade gets surprise help.