A hostage situation erupts at the East Miami Police Department, and Rosewood, Villa and Slade are trapped on the inside. Rosewood forms a strong bond with their captor and must solve his biggest medical mystery to date in order to keep his team alive.

The team is thrown for a loop when the mummified body of a notorious music producer is found on a yacht. Meanwhile, Rosewood is forced to deal with a shocking revelation about Tawnya.

Rosewood and Villa head back to Villa’s roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant

Rosewood and Villa are pulled into the world of human trafficking to investigate the death of a school teacher, and a surprising insight into Slade's past draws Rosie and Villa closer than ever before.

Rosewood, Villa, Slade and Hornstock work to take down a highly skilled group of criminals suspected of a jewelry store heist, and Rosie decides that someone from the inner circle should run a new Magic City Lab on the west coast.