Twin brothers Vincent and Frankie Martino navigate their way through the rough-and-tumble world of 1971 Times Square. Vincent crosses paths with other midtown denizens while plotting to improve his situation. Abby gets enlisted to buy amphetamines.

Vincent moves into a seedy hotel and contemplates an offer from mob capo Rudy Pipilo. Bobby hopes to take advantage of Vincent's new connections. Filmmaking intrigues Candy. C.C. shows Lori the benefits of having a pimp. Larry feels unsettled.

Rudy dangles a lucrative offer in front of Vincent. Longo uses strong-arm tactics to restore order among Bobby's unhappy construction workers. Candy attracts unwanted attention and is intrigued by a legitimate suitor. Paul questions his place at the Hi-Hat. Frankie hits a hot streak. Darlene gets a gift from Abby. Alston sees through Sandra. Bristling after a police shakedown, Vincent adds muscle in the person of Black Frankie, a Vietnam war vet.

In the Season 1 finale, Vincent balks at getting in deeper with Rudy, as expansion fever hits Frankie and Bobby. Candy gets a taste of directing, and enjoys the red-carpet perks of a major premiere. Alston finds himself in limbo at his precinct. Abby changes up the Hi-Hat's clientele; Sandra faces editorial and legal hurdles; Vincent settles a score.

Times Square, 1977. Vincent is now proprietor of a new mob-backed disco, while his girlfriend Abby has brought the nascent punk-rock culture into the Hi-Hat. Vincent's twin brother Frankie remains a problem, "borrowing" money from the sex emporium he manages to pay off his debts. Meanwhile, Candy looks to make more artful, ambitious adult films.

Kiki finds new partners for a deal for Lori. Vincent visits his father for advice. C.C want to get payed for Red Hot.

On the eve of 1985, a worn-out Vincent reconnects with his ex-wife, Andrea, as his open relationship with Abby grows more distant. Despite becoming a family man, Frankie continues his risky side hustles. With the newly dominant VHS format shaking up their industry, Candy and Harvey travel to Las Vegas for an adult film convention. Now a bartender at the Hi-Hat, Loretta becomes an active member of Women Against Pornography.

A struggling Lori turns to Candy for help before revisiting The Deuce. Candy makes a surprising deal to secure funding for her film. Abby takes a stand against the latest phase of Midtown redevelopment. Tommy explains the new world order to Vincent.

Big changes come to The Deuce as Gene sees opportunity in the city's public health crisis. Vincent looks to get out from under the mob's thumb and makes peace with Abby. Candy makes a critical choice in her relationship with Hank. Series finale.