Twin brothers Vincent and Frankie Martino navigate their way through the rough-and-tumble world of 1971 Times Square. Vincent crosses paths with other midtown denizens while plotting to improve his situation. Abby gets enlisted to buy amphetamines.

Vincent moves into a seedy hotel and contemplates an offer from mob capo Rudy Pipilo. Bobby hopes to take advantage of Vincent's new connections. Filmmaking intrigues Candy. C.C. shows Lori the benefits of having a pimp. Larry feels unsettled.

The appearance of an unexpected partner surprises Vincent. Rudy buys into a rival's plan to reconfigure the Deuce. Candy considers entering the filmmaking business. Abby languishes in her new job. Darlene works overtime to compensate Larry.

Rudy dangles a lucrative offer in front of Vincent. Longo uses strong-arm tactics to restore order among Bobby's unhappy construction workers. Candy attracts unwanted attention and is intrigued by a legitimate suitor. Paul questions his place at the Hi-Hat. Frankie hits a hot streak. Darlene gets a gift from Abby. Alston sees through Sandra. Bristling after a police shakedown, Vincent adds muscle in the person of Black Frankie, a Vietnam war vet.

Looking for a way out of his construction gig, Bobby tries to change Vincent's mind about Rudy's offer. Darlene returns from a trip home with a new girl, disappointing Abby. Roughed up by a john, Candy contemplates a change of careers. After getting busted, Paul explores the underbelly, and the exhilaration, of gay life in the city. With an assist from Alston, Sandra scores a key interview with a pimp.

An end-of-the-year crackdown by police in and around The Deuce sparks Vincent and Bobby. Candy tries to persuade Harvey, her adult-film director, that she can do more than act. Rudy witnesses a pivotal lower-court ruling on obscenity, and enlists Frankie and Big Mike to protect his interests in the peeps. Alston tries to convince Sandra that he's not just a “source.”

With police pushing their business off the streets, C.C., Larry, Rodney and other pimps worry about becoming obsolete. Candy eyes a different job on Harvey's set as Lori struggles with the demands of porn acting. At her wit's end, Ashley hangs out with Frankie and, later, washes up on Abby's door. Bobby is smitten with an employee.

Lori envisions a sunny future in LA after attending the AFAA Erotica Awards with Harvey and Candy, who's looking to connect with west-coast producers willing to turn her fairy tale into reality. Paul and Kenneth approach Vincent about a loan for a new nightclub, free from mob ties. Goldman visits Alston's precinct to share the mayor's vision for cleaning up the Deuce.

Temporarily flush with cash, Frankie is tapped by Candy to be a co-producer on Red Hot. Lori eyes a plum role in the film, but still feels the burden of being under C.C.'s yoke. With Rudy's blessing, Big Mike and Black Frankie hit a gambling house in the Bronx. Bobby finds himself stigmatized at home and at the Hi-Hat after a surprise raid overseen by Alston.

Candy shoots her opus guerilla-style on the streets of New York. Vincent makes a confession to Abby, along with a promise to change. Ashley and Abby help a prostitute escape the Deuce, with a little help from Vincent. Larry Brown gets a promotion. Paul celebrates the opening of his new upscale club. Bobby turns to Vincent to find work for his wayward eldest son, Joey.

Trapped by his own success, Vincent envisions an idyllic rural life with Abby. Candy is frustrated by her mob backers' misogyny and weighs telling her son, Adam, what she really does for a living. Shay reverts to form, to Irene's dismay. Joey falls in love. Darlene deals with unexpected news. Lori hits a roadblock in her quest for adult-film stardom. Alston faces a dilemma.

Kiki finds new partners for a deal for Lori. Vincent visits his father for advice. C.C want to get payed for Red Hot.

"Red Hot" premieres as Candy, Harvey and Frankie get caught between competing investors. Vincent and Abby must deal with an unexpected loss. Lori is affraid to go to L.A. without C.C.'s permission. Paul turns to a familiar source to help finance Tod's Dreams. Darlene comes clean.

Frankie takes his amateur porn business to the next level and ends up in a confrontation with Rudy, who pushes Vincent to up his profits. Candy brainstorms a new film based on the experiences of her fellow sex workers and finds that her new beau Hank is not shaken by her past. Abby and Loretta take care of Shay when she shows up to the Hi-Hat in bad shape.

A distraught Vincent follows a lead down a dangerous path. Paul reaches out to Tod's parents. Candy battles Harvey over her latest script. Lori hits the feature dancing circuit. Abby reflects on her choices. Bobby does right by Black Frankie. Alston defends the plan to clean up Midtown. Gene reckons with his conflicted personal life.

Big changes come to The Deuce as Gene sees opportunity in the city's public health crisis. Vincent looks to get out from under the mob's thumb and makes peace with Abby. Candy makes a critical choice in her relationship with Hank. Series finale.