Driven out from his orphanage, Nakajima Atsushi wanders the streets of Yokohama on the bring of starvation. Determined to live, a chance encounter with a drowning stranger changes his fate...

Francis, the leader of The Guild, a North American organization of gifted members, is the one responsible for the bounty on Atsushi's head. Fukuzawa refuses Francis's offer to buy out the Agency, but their agents begin to disappear...

The leaders of the Agency and the Port Mafia negotiate an alliance. Meanwhile, Dazai and Chuuya face off against Lovecraft.

The café that the Detective Agency members frequent is attacked by The Park, who are after the Guild’s property.