The leaders of the Port Mafia and the Detective Agency are attacked by an assassin in a mask, leaving both of them ill.

The Detective Agency president is in safe hands for now, but unless he or the Port Mafia boss dies, a full-scale war between the two organizations is inevitable.

Mori Ougai and Fukuzawa Yukichi fight to the death in a desperate bid to save the organizations they lead from falling into a devastating war.

The gifted responsible for the virus is on the run as Nakagawa Atsushi and Akutagawa Ryunosuke chase after him. Meanwhile, the Detective Agency has the Rats’ hideout surrounded to try to capture Fyodor Dostoevsky.