The Runaways are feeling more fractured than ever when Molly arrives with a devastating message from her parents. Now the kids have to stop their parents before it’s too late.

Angry at his betrayal, the Runaways meet with Chase. He offers them a choice: surrender to PRIDE or face the consequences. As the kids attempt their escape, they’re separated and forced to survive against an enemy far more pernicious than they expected

The kids search for Leslie and Alien Alex. Meanwhile, Leslie gives birth and Xavin fulfills her prophecy. The kids go head to head in a final battle against the aliens.