To investigate the cost and availability of AIDS medication needed in Africa, the White House plays host to representatives of American pharmaceutical companies and the president of an African nation; C.J. accidentally leaks information to a freshman reporter; after Sam is shown up by an amateur Republican operative on a television program, Jed decides to hire her.

Leo tries to make Ainsley's arrival as painless as possible, despite resistance from her new boss and several other White House staffers; Donna helps with the President's weekly radio address; C.J. tries to derail a retiring General's attempt to speak out against Bartlet; Sam gives Josh ideas on how to deal with his insurance company.

The president considers recalling the Senate to push ratification of a nuclear-test-ban treaty. Meanwhile, Donna lobbies new legislation introducing ergonomic standards in the White House; A Ukrainian politician shows up at the White House drunk demanding to see the president.

After ridiculing Notre Dame, C.J. is forced to accompany the President on a trip to Oregon; Toby and Sam struggle to write Jed's education speech for the following day; back at the White House, Josh tries to dissuade a gay Congressman who supports legislation banning same-sex marriages and Leo gets divorce papers, which causes Margaret to worry that he may fall off the wagon.

The President delivers his 3rd State of the Union address, what critics call "the speech of his political career" and ends up angering Abbey by what he does and doesn't say; Josh must work the polling center with Joey Lucas, but a power outage delays the results; Sam attempts to introduce Ainsley to the President with disastrous results; CJ must juggle a live recording of the show "Capitol Beat" being broadcast within the White House and run damage control when a cop has a (possibly undeserved) black mark on his record; Leo and Bartlet must handle the matter of five DEA officials who are taken hostage by Columbian terrorists.

Bartlet authorizes a special ops team to rescue the five DEA agents only to have them caught in an ambush; CJ arranges for the host of "Capitol Beat" to have an exclusive interview with the wronged police officer; Toby must deal with Senator Gilette who threatens to make a third party run for president due to the tone of the changes on social security reform; Sam gives Ainsley another chance to meet the President, but she still fails to create a good impression; Josh finally gets the poll results from Joey; Abbey and Bartlet discuss his running for a second term.

Toby, suspicious that there's something going on with the President, finds out about Bartlet's MS and informs Leo of the legal ramifications; Josh and Donna disagree about the date of their "anniversary"; Sam and Ainsley argue about the necessity of the ERA; staffers struggle to punch-up the speech the President will give at the White House Correspondents Dinner.

Bartlet confers with Babish on the legal ramifications of his MS cover-up; Sam has a personal interest in an oil spill off the coast of Delaware; Josh and Donna argue about a loan to Mexico; Toby orders C.J. to flush out a leak in the White House staff, which is far from easy.

The Special Prosecutor sets his probe in motion; Sam and Bruno are concerned about the loyalty of a powerful labor leader; Toby and Josh are preoccupied with a congressional battle over the estate tax; Ainsley fixes up Donna with a Republican.

Stanley Keyworth revisits the White House to uncover the reason Bartlet hasn't been able to sleep since the night of the Iowa caucus; C.J. enlists Leo's help in freeing a White House reporter kidnapped while on assignment in the Congo; Toby and Andy joust over an upcoming presidential speech condemning Islamic fanaticism by name; Donna is offered a lucrative dot.com job by an old friend; Sam sparks an exchange on radical versus lipstick feminism when he comments on Ainsley's evening attire immediately after asking her to review language in Bartlet's U.N. address.

Toby looks forward to meeting the new U.S. Poet Laureate; Jed fires the first salvo of his reelection campaign when he calls his likely opponent less than brilliant, and the national press just can't get enough of it; Ainsley gets promoted; Josh overreacts to posts on the message board of a website devoted to "all things Josh".

Former series regulars, including Marlee Matlin, Mary-Louise Parker, Tim Matheson, Anna Deavere Smith and Gary Cole, make guest appearances as Bartlet, Santos and their staff members attend a funeral for one of their own. Also, Josh cautions Santos about getting involved in the vote for Speaker of the House.