A senator attaches a rider to the federal budget bill that would ban gay marriage, almost daring the President to veto it, as the physical infirmities of Bartlet's MS become more pronounced. The Internet is rampant with a story that questions CJ's sexual orientation, and it is only fueled further when CJ refuses to dignify the allegations by putting out a statement. Donna joins the Vice President's senior staff, and heads for New Hampshire to start up Russell's presidential campaign there. And Santos decides that he will run for president after all, but only if Josh will leave the White House to manage his campaign.

The presidential candidates journey to Iowa, where democrats Russell and Santos, and republican Vinick, are all told by their handlers that when they appear before before the corn growers association they must support subsidies for the use of corn-derived ethanol as fuel, regardless of their true feelings.

Santos is campaigning in California during the last few days before the all-important "Super Tuesday" primary elections, but he is out of money and he trails both Russell and Hoynes in the polls. When even "La Palabra", a Latino voters group, is all set to endorse Hoynes instead of Santos, Josh urges Santos to take a stand on the new bill that denies driver's licenses to illegal immigrants. Meanwhile, Donna tries to figure out why Hoynes suddenly isn't campaigning in California, and advances her position in the Russell campaign by becoming the Vice President's official spokesperson.

Faced with a Democratic party in disarray in the face of the strongest Republican challenger they have ever had, Bartlet asks Leo to take charge of the potentially chaotic Democratic National Convention, while Santos considers a party-unifying vice-presidential offer from front-runner Russell. Meanwhile, the International Space Station is leaking oxygen and a rescue of the three astronauts will be difficult, and Bartlet catches Charlie leaving Zoey's bedroom after a nighttime visit.

At the Democratic National Convention, Russell, Santos and Baker jockey for the 2162 votes that will give one of them the nomination for President, and the opportunity to lose to the apparently unstoppable Vinick in November. Meanwhile, the President must make a decision before it's too late on whether to deploy a secret rescue mission to the space station, and the FBI is asked to determine who leaked the existence of the military shuttle to the press.

As everyone but Josh causes Santos to question his choice of Leo as his running mate, Bartlet's investigation into the dangerous press leak continues. Also C.J. gets interviewed by Babish and Donna approaches Josh for a job.

The White House is trying to cope with the revelation of the identity of the leaker and Babish's questioning of Toby convinces him that he must get his lawyer. Lou persuades Josh to get Santos to clean house with his campaign staff. Kate finally reaches Charles Frost and confronts him about what he told to C.J. and a few other things about his personality in general. The Bartlets hear Ellie's heapful of "good" and "bad" news.

Santos and Vinick battle it out in primetime live. Forrest Saywer the moderator poses questions and attempts to ensure that the candidates remain within bounds. Ellen DeGeneres guest hosts the show on behalf of American Express and their new credit card.

Lou and Santos run into trouble on the road when they try to pick up a family's vote; their child was shot by a Latino police officer. Also, CJ must manage a crisis between China and Kazakhstan.

All eyes are looking forward to the Leo McGarry/Ray Sullivan Vice Presidential debate. Meawhile, Santos is trying not to catch his children's cold and he visits his home in Texas and continues to campaign. Jorge Santos, the Congressman's brother, may cause some problems at a gathering.

Bartlet must deal with the possiblity of a nuclear explosion in California, Kate is keeping a careful watch on the election in Kazakhstan and China's response, Will is acting as the government's voice this week, and Josh is trying to keep his political version of Tourette's in check.

The Santos campaign meets up with Rock the Vote and lots of musicians are around for a star-studded episode. Helen gives a lecture to MANA (a National Latina Organization, formerly Mexican American National Association) but her heritage doesn't help her when trying to deliver part of the Santos campaign message. Toby is being pressured by the Attorney General, Blake, to reveal his source and it's affecting his relationship with his kids. He tries a little psychological warfare of his own to get Blake to back down. Toby is also giving Josh campaign advice which includes plans to increase courtship of the Latino vote. Elsewhere on the campaign trail, it's Halloween and Toby's kids and Santos' kids are dressing up for the occasion.

Election Day finally arrives, and between analyzing exit polls, and mulling over news reports, a few Santos staff members discover the joys of campaign romance. Meanwhile, C.J. ponders life after the White House; and Annabeth makes a tragic discovery.

Abbey is in New Hamphire with Liz Bartlet-Westin and they are awaiting the results of Doug Westin's campaign for a seat in Congress. Members of both the Santos campaign and the Vinick campaign must decide how to handle a tragedy, as the voters around the country continue to cast their votes for the next President of the United States.

Former series regulars, including Marlee Matlin, Mary-Louise Parker, Tim Matheson, Anna Deavere Smith and Gary Cole, make guest appearances as Bartlet, Santos and their staff members attend a funeral for one of their own. Also, Josh cautions Santos about getting involved in the vote for Speaker of the House.

Former cast member Rob Lowe returns as a senior political official in this episode, which finds Bartlet and his staff making the transition as easy as possible for the president-elect, who discovers some unpleasant realities about his new job. Meanwhile, a stressed-out Josh realizes that he may need to take some time off after he reaches his breaking point.

While Santos is busy trying to select a new vice president, his wife finds her new responsibilities staggering. Meanwhile, Vinick ponders his next move.

After seven seasons of the Award-winning drama series, the Bartlet Administration prepares to leave the White House and The West Wing. While Santos and his winning camp are nervously gearing up for the presidential inauguration, current President Bartlet (Martin Sheen), CJ (Allison Janney) and the others fondly look back as they prepare to leave the White House forever.