Lynette locks horns with officious mom Maisy Gibbons at the twins' school who is trying to produce a "politically correct" play about "Little Red Riding Hood." Meanwhile, Susan continues to investigate the mystery of Zach's sudden disappearance. She soon finds out his father Paul put him in Seacrest, a mental institution. She and Julie then go to investigate.

Mama Solis comes closer to discovering Gabrielle's dirty little secret of her affair, and Bree comes undone when Rex suggests they hire a sex surrogate.

Susan and Edie decide to follow Mike and his houseguest Kendra on their night out together. Lynette becomes steadily more dependent on the twins' ADD medication. In the meantime Gabrielle becomes jealous of the "other" woman in John's life. And Bree's kids mutiny when they learn their dad has moved out. Tom is not happy when Lynette tries to take over his concept of new "Spotless Scrubs" to his clients.

Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.