Looking down on her friends and family isn't a way of life for Mary Alice Young. It's a way of death. One day, in her perfect house, in the loveliest of suburbs, Mary Alice ended it all. Now she's taking us into the lives of her family, friends and neighbors, commenting from her elevated POV. Her husband's acting suspicious, the neighbors are talking, and her girlfriends are wondering why one of their own would do something so rash… and so messy.

Mike's dog pays the price when Edie crashes his dinner date with Susan. Meanwhile, Gabrielle realizes that her lawnboy is taking their fling to heart - and that Carlos may actually be catching on. Also, Bree goads Rex into therapy, where the doctor may be the one who needs the most help. Lynette resorts to drastic measures to keep her kids in line, but it blows up in her face.

The women decide to go ahead with the big dinner party that the late Mary Alice Young had planned to host, despite the more-than-minor disturbances in their own lives. Adulterous Gabrielle finds herself with a nine-year-old blackmailer who catches Gabrielle in the act in her affair with gardener John. Also, Bree struggles to keep her crumbling marriage a secret. Lastly, Susan bares all--in more ways than one--as she confronts her ex.

Cash-strapped Mrs. Huber figures out that Susan had something to do with Edie's house fire and tries to blackmail her. Meanwhile, Carlos becomes suspicious that Gabrielle is seeing another man, but targets the wrong suspect---the cable guy instead of gardener John. Also, Lynette balks when the twins' teacher insists the boys have ADD but tries to salvage the matter by seprating the boys. Lastly, Bree struggles with her rebellious son Andrew after Rex moves out.

A break-in on Wisteria Lane leaves the neighbors feeling vulnerable, especially Susan, who reluctantly accepts a date with a persistent policeman after Mike appears indifferent to her. Rex takes the kids away for the weekend as a lonely Bree finds herself bonding with Zach. Meanwhile, Lynette and Tom pull out all the stops to get their uncontrollable twins Porter and Preston accepted at a prestigious private school, and the unexpected arrival of Carlos' mother puts a crimp in Gabrielle's covert love life.

Lynette locks horns with officious mom Maisy Gibbons at the twins' school who is trying to produce a "politically correct" play about "Little Red Riding Hood." Meanwhile, Susan continues to investigate the mystery of Zach's sudden disappearance. She soon finds out his father Paul put him in Seacrest, a mental institution. She and Julie then go to investigate.

Mama Solis comes closer to discovering Gabrielle's dirty little secret of her affair, and Bree comes undone when Rex suggests they hire a sex surrogate.

Susan and Edie decide to follow Mike and his houseguest Kendra on their night out together. Lynette becomes steadily more dependent on the twins' ADD medication. In the meantime Gabrielle becomes jealous of the "other" woman in John's life. And Bree's kids mutiny when they learn their dad has moved out. Tom is not happy when Lynette tries to take over his concept of new "Spotless Scrubs" to his clients.

In the aftermath of tragedy with Bree's son Andrew running over Carlos' mother Juanita Solis, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike's real reason for moving to the street. Lynette reaches the breaking point in her addiction to the twins' ADD medication as she tries other measures like acupuncture to release her stress. The mysterious Mr. Shaw gets down to business as he develops a relationship with Edie. Lastly, Gabrielle confesses her adulterous affair to a priest while Carlos' mother Juanita is in the hospital.

Looking to give her life a purpose, Gabrielle decides to organize a glamorous Halston fashion show for charity highlighting the ladies of Wisteria Lane. Bree and Rex are at odds on how to punish Andrew for putting Mrs. Solis in the hospital and finding drugs in his room. The police investigate a toy chest that Paul Young dumped in the river. Lastly, Lynette uses her business acumen to poach a nanny, Claire, but ends up getting involved between her current employer, Alexis.

Uber mom Maisy Gibbons returns, and her secret life intersects with Bree's. Meanwhile Gabrielle's predicament worsens as she gets a taste of her own medicine, courtesy of Carlos's jailhouse confession. Susan plans to take her relationship with Mike to the next level, and Lynette, suspicious (and a little jealous) of her new nanny decides to secretly videotape her. Lastly, Susan sends Zach Young back home to his father, who makes a startling admission of his own.

Edie organizes a neighborhood search for the missing Mrs. Huber, just as the absent busybody's sister Felicia Tilman arrives on Wisteria Lane. Meanwhile, Bree resigns herself to her marital state and asks an attractive pharmacist on a date. Susan's ex Karl suddenly reappears in her life, and Lynette fears that Tom is attracted to the new nanny. Lastly, Gabrielle sinks to new depths.. she gets a job.

The residents of Wisteria Lane finally learn Martha Huber's fate. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George getting a little too close for comfort. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

When Lynette's father-in-law pays a visit to to the family, she unwittingly learns a family secret. Meanwhile, Susan is disturbed by Julie's growing romance with Zach. Rex attempts to reconcile with Bree as she tries to play hard-to-get. Lastly, Gabrielle is shocked when John's parents ask her for a favor in convincing John to move back home as he officially turned eighteen and no longer wants to live at home and trying to pursue a relationship with Gabrielle.

It's Valentine's Day on Wisteria Lane, and love is all around (sort of), as Susan looks forward to a romantic date with Mike, until she learns a surprising fact about her favorite plumber. Meanwhile, after reconciling their relationship, Bree discovers something new about her husband Rex when it comes to his sexual needs. Lynette's neighbor accuses the Scavo twins of thievery as Lynette tries her best to handle the situation. Lastly, Gabrielle's work adventures continue as she gets a gig as a mattress model.

Mike Delfino is questioned about Mrs. Huber's murder by police and is arrested. John's friend, Justin attempts to blackmail Gabrielle with his knowledge of their affair. Meanwhile, Tom wants a big promotion, but Lynette fears that she'd be home alone with the kids more than ever and tries her best in discouraging him in taking the job. Also, Bree is shocked when she finds a condom. Zach Young plans a pool party for the teens on Wisteria Lane, and things get out of hand. Finally, someone comes out of the closet.

Maisy Gibbons' series of unfortunate events shock the residents of Wisteria Lane when she is finally caught and arrested for prostitution. This leaves unexpected consequences for Bree and Rex when Maisys' little black book becomes public of all her clients.

Gabrielle and Carlos also face a crisis of their own when the sewer system goes out at their house. Also, Lynette braves a scandal herself when it's rumored that the twins started the school's head lice epidemic. Meanwhile, as Susan sinks into depression over her breakup with Mike, she finds a surprising ally.

The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.

Susan's mom pays an unannounced visit to Wisteria Lane after she and her boyfriend call it quits. Meanwhile, Gabrielle faces Carlos' wrath after he learns about the hospital settlement and tries to change their prenuptial agreement in order to keep Gabrielle in check while he serves his jail sentence. Lynette and Bree experience a chill in their friendship after Bree babysits Lynette's kids and dares to discipline Porter. Also, Bree and Rex visit Andrew at the teen rehab camp where they learn some shocking news about their son. Lastly, Felicia gets closer to Zach and reveals some disturbing details about his family in the past.

Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.

Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.

Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.

Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.

Bree confides that she feels guilty because she and Rex were having a fight when he had his heart attack and that now he needs a pacemaker. Lynette's marriage takes a dramatic turn after an upset Tom vows that it is now her turn to go back to work and he'll be staying home with the kids. Carlos finally learns that John and Gabrielle have been lovers for a while, and vows revenge as he is carted off to jail. Mike takes Paul out to a deserted quarry, intending to shoot him.

The new neighbors, the Applewhites have moved in. Gabrielle, Lynette, and Susan attempt to comfort Bree while Rex's mother arrives on Wisteria Lane for his funeral. Meanwhile Mike and Susan deal with Zach while Gabrielle struggles with the two men in her life.

Susan is surprised when she finds out who Edie's new boyfriend is. Meanwhile, Lynette has gone back to work, leaving Tom at home in charge of the house. Carlos makes an unusual request to Gabrielle after his life is threatened behind bars. Lastly, pharmacist George reemerges in Bree's life, which sets off an alarm to mother-in-law Phyllis and her suspicions surrounding her son's death.

Susan tries bravely to accept Edie’s new role in Julie’s life, while Lynette’s demanding boss makes her miss Parker’s first day of kindergarten. Bree later on takes a polygraph test to prove her innocence in Rex's death and realizes she has feelings for George.

Gabrielle finally comes to the truth about Carlos and John after seeing John with another woman.

On one of Gabrielle's prison visits to see Carlos she creates a terrible riot, which lands Carlos in hot water. Also, Susan puts her feelings aside and joins Mike in searching for his son Zach. Lynette is surprised to find out that her son Parker has an imaginary friend. Lastly, George and Andrew both vie for Bree's attention as they both compete in making each other look bad in front of her, until one fight goes a little too far.

Susan's longtime book agent and dear friend, Lonny Moon gets into financial trouble. Lynette is forced to go out to bars night after night with her man-hungry boss, Nina. Bree finds out about Rex's feelings about her prior to his death. Lastly, Gabrielle hires hotshot lawyer David Bradley to defend Carlos in court but Carlos rejects him after he witnesses an attraction between David and Gabrielle.

Mike and Susan face a crisis in their relationship when Susan tries to get Paul Young arrested by confessing to a police officer that he killed Mrs. Huber and Mike has her diaries as proof. The officer goes over to Mike to get the story, but Mike denies the whole thing. As Carlos continues serving his jail sentence, Gabrielle valiantly tries to free him. Bree goes to a romantic hotel with George, but requests they sleep in separate rooms.

Gabrielle tries to revisit her past when old friends come to town, but doesn't want anyone to know that she's three months pregnant. With the aftermath of her breakup with Mike, Susan finds temporary solace from her ex-husband Karl as his relationship with Edie hits a bump. Also, the Scavos learn more about the new neighbors, the Harpers when they babysit their children and uncover a sex tape of the couple. Lastly, Caleb gets loose from the basement and roams around Wisteria Lane at night, which leads to major consequences for Gabrielle.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.

George stalks Bree, despite her efforts to break up with him. Lynette takes charge of office politics. Carlos is paroled from prison and returns a new man, and Gabrielle is jealous of his new 'holier-than-thou' confidante. Susan meets her birth father and tries to begin a relationship with him.

Lynette tries to put a daycare center in Parcher & Murphy by recruiting employees' children to get the program started. Gabrielle and Sister Mary Bernard face off over Carlos' mission of mercy to Africa. Bree brings Andrew home and tells him about the revelation of George poisoning his father Rex and killing him. Lastly, Susan confronts her biological father's wife after she thinks they are having an affair.

Gabrielle kisses Tom and Lynette is not happy and drives a wedge in her friendship with Gabrielle. Paul attacks Mike. The housewives become more suspicious of Betty and her family. Andrew is trying to blackmail Bree, but Bree gets some assistance from Susan's ex, Karl.

After a number of bad dates, Susan finally meets Dr. Right. Susan flirts with a handsome doctor, but they accidentally head butt. Meanwhile, some old pictures of Gabrielle turn up on the Internet. Tom is alarmed when his kids come down with chicken pox because he never had it. Bree gets arrested. Lastly, after months of silence, Noah Taylor contacts Mike Delfino.

Dr. Ron informs Susan that she needs a splenectomy. Gabrielle and her arch-enemy Sister Mary Bernard finally face off in church.

Also, Tom decides to apply for an empty position at Lynette's job, which leads to the arousal of past issues in their marriage. Lastly, Matthew and Danielle's relationship is found out by both their mothers, which leads to big repercussions later on for Bree and her past secret with Andrew last year.

Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Susan invites Dr. Ron to meet Karl after he finds out about their arranged marriage. Lynette is surprised that a woman at work is still breastfeeding her child of five. Gabrielle becomes very picky when choosing a birth mother, and a beautiful baby. Bree has to deal with a fresh accusation from Andrew, that of repressed memories.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

Gabrielle and Carlos are shocked when the father of their baby shows up to take the baby back. Cops and a lawyer arrive to a house on Wisteria Lane. Lynette tries to help Ed heat up his sex life. Meanwhile, Karl decides to break up with Edie, as Edie has no idea that Susan is the "other woman." Edie causes a fight to break out in a bar, after she trips a waitress. Lastly, Bree is taken a step forward to help Peter when she finds out how bad his other addiction is.

Bree and Andrew finally reach an impasse in their relationship as tension has finally reached a critical point. Meanwhile, Ed finally fires Tom with the pressure from his wife. Lastly, Edie's private detective begins to uncover numerous details of Karl and Susan's relationship as of recently. Gabrielle is having a tough time keeping her servant in the country.

Reaching the end of her rope, Bree checks herself into the Fairview psychiatric hospital. Lynette suspects that Tom is cheating on her, so she follows him to Atlantic City. Susan must start over. Felicia Tilman has more in store for Paul Young, resulting in their war reaching its final battle. Gaby and Carlos get Xiao-Mei pregnant.

Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.