Desna's plan to sell Oxy to a higher-class clientele is quickly sabotaged by Uncle Daddy and Quiet Ann, escalating the drug war.

Desna launches Claws Up, her new multi-level Oxy sales operation, employing some of her most loyal clients as dealers and recruiters - Ã la Mary Kay. Tension rises for the crew as they attempt to manage a criminal enterprise from the top.

Desna and her crew begin to enjoy the benefits of their newfound success until it's discovered someone is stealing and reselling their pills under a different label. Desna and her girls must confront this person - with deadly consequences.

Feeling guilty for Jenn and Bryce losing custody of their children, Desna offers them use of her condo, where Jenn begins secretly taking Oxy to steady her nerves.

Desna opens up a second nail salon but a rival salon owner soon demands a monthly payoff, forcing Desna to take drastic measures. Jenn's Oxy addiction spirals out of control as she forms a suspiciously close bond with Tony.

Desna vows not to rest until she has dismantled Uncle Daddy's organization from the inside out. Jenn's questionable friendship with Tony is discovered by both Desna and Bryce, threatening to destroy both relationships.

With the realization that Tony is an undercover DEA agent, Desna must rally her crew to avoid being taken down by the feds. But when Jenn ODs, the crew begins to uncover buried truths that threaten to unravel their tight-knit bond.

With the crew in shambles and the threat of the DEA looming, Desna plots an exit strategy for herself and her girls. Her plans are accelerated after Bryce kills Tony in a jealous rage and then confesses it to Uncle Daddy.