Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure hospital’s surgical unit. Alone in the world and unable to personally connect with those around him, his only advocate, Dr. Aaron Glassman, challenges the skepticism and prejudices of the hospital’s board and staff when he brings him in to join the team. Shaun will need to work harder than he ever has before, as he navigates his new environment and relationships to prove to his colleagues that his extraordinary medical gifts will save lives.

Dr. Shaun Murphy’s attention to detail complicates his first day at St. Bonaventure Hospital. Meanwhile, Dr. Claire Browne learns a valuable lesson about honesty when confronted with a difficult diagnosis for her patient.

Dr. Neil Melendez and Dr. Jared Kalu discover their patient isn’t being completely honest with them which may cost him his chance at a life-saving surgery. Meanwhile, Dr. Claire Browne must learn to communicate with Dr. Shaun Murphy as they race back to St. Bonaventure Hospital with a donated organ.

Dr. Neil Melendez and the team have to wade through legal waters when a husband and wife have to make a life-changing decision about their unborn child. Meanwhile, Dr. Shaun Murphy struggles to adjust to his new environment at home and makes a huge step forward with his colleagues.

While in the exam area of St. Bonaventure Hospital, Dr. Shaun Murphy encounters a young patient who looks eerily similar to his deceased brother, Steve. After discovering his parents have hidden his diagnosis from him, Shaun struggles to understand why he doesn’t deserve to hear the truth about his own health. Meanwhile, the team can’t figure out what keeps triggering their patients’ increasingly severe allergic reactions and races to find the cause before the next one kills another patient.

Dr. Shaun Murphy and Dr. Claire Browne devise an experimental procedure that can save the leg and life of a young groom, that is if his bride-to-be and parents can learn to work together. Meanwhile, Jared struggles to emotionally connect with his patient whose scars may prove too deep to overcome.

Dr. Shaun Murphy has to confront prejudice from an unlikely source when he takes on the case of a patient with autism, and Dr. Jared Kalu has to learn to accept his limitations as a surgeon.

During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun's traumatic day, Dr. Aaron Glassman worries that he isn't doing enough to help Shaun.

As part of St. Bonaventure hospital's international humanitarian program, the team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Dr. Neil Melendez has doubts about the safety of the procedure, while Dr. Shaun Murphy works out the best course of action. Meanwhile, Murphy's latest encounter with his neighbor Lea has him confused.

A charming young doctor puts a member of the surgical team in an awkward position at work; Dr. Glassman suggests that Dr. Shaun Murphy meet with a therapist.

Dr. Marcus Andrews enlists Dr. Neil Melendez on a very sensitive kidney transplant between a pair of twins; Dr. Shaun Murphy decides to take an impromptu trip with his friend Lea and leave his problems behind.

The twins suffer complications from their surgery forcing the team at San Jose Boneventure Hospital to make a life-changing decision. Meanwhile, Dr. Shaun Murphy returns to the hospital after his trip with Lea and decides he needs a more permanent change and gives Dr. Aaron Glassman his two weeks’ notice.

Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez’s personal life could be affecting his work and, ultimately, his patients lives.

Dr. Shaun Murphy is surprised to learn that his young cancer patient identifies as a girl while being biologically male. Shaun must quickly learn to understand his patient, her medical needs and how to work with her family, who all feel they know what is best for her.

Dr. Shaun Murphy's teenage patient has been confined to her home her entire life due to a rare heart condition. Despite her condition, she has cultivated a large group of friends online and hopes that the surgical team can find a way to give her the life she has always dreamed of having. Meanwhile, a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.

When the team treats a patient who has to decide between a dangerous surgery that could change his life or remain the same, he asks Dr. Shaun Murphy what he would if he had that same choice.

Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.

The team at St. Bonaventure needs to quickly discover the truth behind a young college student’s unexplained injuries before his condition worsens. Meanwhile, after losing his most prized possession, Shaun’s distraction during a surgical procedure may end up risking more than just his job.

Shaun’s proposed treatment for a homeless patient puts him and Dr. Kalu in Dr. Andrews’ crosshairs. Claire tries to overcome Dr. Melendez’s reluctance to do a risky heart operation. Dr. Glassman faces a difficult decision about his health.

As Shaun pushes back against Dr. Melendez in order to treat a gravely ill hospital janitor, Dr. Lim risks a lawsuit to repair a teenage girl’s ritual circumcision. Dr. Glassman exercises demanding oversight in choosing a doctor for his brain surgery.

Dr. Melendez, Dr. Brown and Dr. Park have given a young married couple two choices about their future: save the wife’s life or their future ability to start a family. Meanwhile, when Dr. Lim has to take care of some personal business, she leaves oversight of the emergency room to Dr. Murphy and Dr. Reznick; and Dr. Glassman’s post-op recovery leaves him struggling to get the rest he needs for recovery and also confronting his relationship with his daughter.

Shaun recalls his own past to help an intellectually disabled teenager face separation from his mother, while Claire is put between an injured teenage rock climber and her worried parents. Meanwhile, Glassman’s post-op hallucinations force him to confront a personal tragedy.

When a patient suffering from anorexia can’t gain the necessary weight needed to survive heart surgery, Claire suggests they perform an experimental surgery which Melendez strongly opposes. Shaun worries Glassman’s refusal to walk the hospital floor will keep him from being discharged and tries to persuade him to ambulate. Meanwhile, Shaun and Lea change the terms of their current relationship.

Morgan and Shaun’s indecision on how to treat a young violinist who visits the ER with an infected finger could affect her future in more ways than one. Meanwhile, Lim, Claire and Park can’t figure out if their young patient is really ill or looking for attention.

Dr. Shaun Murphy and Dr. Morgan Reznick must contend with two brothers who are bargaining over life and death. Meanwhile, Dr. Claire Brown’s friend who is dying of cancer asks her for something she doesn’t think she can give her; and Dr. Aaron Glassman is dealing with the effects of his treatment.

Dr. Shaun Murphy, Dr. Audrey Lim and Dr. Claire Brown’s E.R. patient is forced to reveal a secret to her husband after their treatment caused a complication. Meanwhile, Dr. Neil Melendez, Dr. Morgan Reznick and Dr. Alex Park struggle with a patient whose parents don’t believe in vaccinations.

Dr. Neil Melendez, Dr. Morgan Reznick and Dr. Claire Brown grapple with a patient’s wish to perform an operation that would keep him from acting on his pedophilic urges; and Dr. Shaun Murphy learns a lesson in empathy.

Dr. Shaun Murphy and Dr. Alex Park treat two patients who collapse at the local airport and whose symptoms point to an infection that may become airborne. The staff races to contain the infection before it spreads to the rest of the patients in the ER, resulting in a hospital quarantine during the holidays.

The hospital is still in quarantine as Dr. Shaun Murphy continues to be overwhelmed by the chaos and noise in the emergency room; Dr. Morgan Reznick struggles to keep her patients alive, and Dr. Audrey Lim fights for her life. Meanwhile, Dr. Neil Melendez and Dr. Claire Browne must find a way to complete their patient’s bone marrow transplant, despite the quarantine.

In the aftermath of the quarantine, the staff tries to return to their normal routines. Meanwhile, as Dr. Lim recovers from the virus, she and Dr. Melendez navigate their new personal and working relationship, while Dr. Murphy and Dr. Glassman visit Lea.

Dr. Shaun Murphy, Dr. Morgan Reznick and Dr. Audrey Lim treat a woman with autism and a delicate brain condition while navigating the complicated relationship she has with her roommate, who is also on the spectrum. Meanwhile, Lea and Shaun are still figuring out their friendship and roommate status.

Dr. Andrews tries to convince a grieving family to donate their teenage daughter’s face to another young girl whose face was horribly disfigured in an accident.

Shaun’s blunt honesty with a distraught mother of a critically ill newborn baby causes the new chief of Surgery to question keeping him on as a resident.

The new chief of surgery, Dr. Jackson Han, believes Dr. Shaun Murphy is a liability more than an asset and works to keep him out of the operating room permanently.

Dr. Shaun Murphy is desperate to join the team on a dangerous procedure involving a patient’s tumor removal. However, having been removed from the surgery team by Dr. Jackson Han, Shaun must use his talents to help figure out the cause of an infant’s injuries.

As a barroom fight sends Dr. Shaun Murphy to seek treatment at St. Bonaventure’s, Dr. Alex Park and Dr. Audrey Lim disagree over an elderly woman’s post-operative symptoms. Meanwhile, Dr. Neil Melendez and Dr. Lim make their romance public, and Dr. Aaron Glassman continues to pursue a relationship with a good friend.

Shaun and Lea’s long-awaited wedding reception is interrupted by a violent attack at the hospital and the entire team must mobilize to save the victims. Meanwhile, the trauma of seeing people he cares for in life-threatening situations is affecting Shaun in more ways than one.

On their first day as surgical attendings, Dr. Shaun Murphy and Dr. Alex Park are introduced to the first year residents they will be overseeing, Dr. Danica Powell and Dr. Daniel Perez,who make quite the first impression. Meanwhile, Lim returns to work while facing her new reality and the emotions surrounding the changes.

The team treats a famous marriage counselor after she injures her ankle from falling, but when she offers relationship advice to them, Dr. Morgan Reznick quickly spots that their patient might be experiencing something far more serious. Meanwhile, Dr. Audrey Lim is determined to get to the bottom of what really happened in the OR during her surgery and sets off on her own internal investigation.

The team operates on a military reenactor whose attempt at authenticity has created an explosive predicament that even Dr. Shaun Murphy couldn’t predict. Meanwhile, Dr. Jordan Allen and Dr. Daniel Perez are on a race against time as they search for a severed foot.

Shaun, Asher and Powell treat a young patient on Halloween with a rare hereditary disease, sending them down an uncharted path. Meanwhile, Glassman and Shaun must overcome their differences to work together to try and find a solution for Lim’s paralysis.

In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives on the 100th episode.

When a woman pregnant with sextuplets arrives at the hospital, Dr. Marcus Andrews must split the doctors into teams to ensure their health and safety following their high-risk delivery. Meanwhile, Shaun and Lea must face their own hurdles as they discuss starting a family.

Drs. Shaun Murphy, Asher Wolke and Aaron Glassman meet a patient with an infected surgical sponge that was left in their abdomen. Meanwhile, Dr. Morgan Park must face her own past when she treats the victim of a sexual assault.

Dr. Shaun Murphy unknowingly creates a competition between Drs. Danica Powell and Daniel Perez when he introduces a new performance rating system; Dr. Morgan Reznick may have crossed a line with Dr. Alex Park.

Shaun and Lea soon learn that their surprise pregnancy may also come with additional complications. Meanwhile, Doctors Park, Reznick and Allen treat a teen with Gardner’s syndrome whose past surgical history jeopardizes the outcome of his current one.

On the way to their babymoon, Lea and Shaun get a quick lesson in parenting when they rush to aid an injured dog. Meanwhile, Dr. Danica Powell secretly performs an operation on a friend that could jeopardize her career.

Shaun invites Aaron to stay with him while he has exterminators at his house and Lea realizes both men have a lot more in common than she realized. Meanwhile, Dr. Morgan Reznick wrestles with a big decision about her career and her personal life.

Shaun and Lea clash over their parenting styles and worry about what will happen to their relationship when their child is born. Meanwhile, Dr. Lim must find a way to save the damaged lungs that one of her long-time patients has been waiting for.

When a 3-year-old arrives at the ER, the team immediately recognizes he is having a stroke. However, Dr. Shaun Murphy’s diagnosis of the underlying cause doesn’t solve the problem which has Dr. Park search deeper.

Dr. Jared Kalu makes a surprise return to San Jose’s St. Bonaventure Hospital with his billionaire patient. Meanwhile, Park must treat the man his wife had an affair with and try to find a way to forgive him.

Dr. Shaun Murphy seeks legal representation to help him win a case and puts his faith in a promising, young lawyer who has obsessive compulsive disorder.

Dr. Shaun Murphy must learn how to work with Dr. Jared Kalu again and remind him that he must start all over at St. Bonaventure. Meanwhile, Dr. Murphy treats a teenager suffering from neurological problems with a very high-risk procedure.

When a patient comes in with persistent and lingering COVID symptoms, the team discovers she may be dealing with something harder to treat. Andrews and Villanueva must contend with their hierarchy at the hospital and its effect on their relationship.

Drs. Andrews and Lim clash over a patient split nearly in half, which also reveals her issues with Dr. Kalu’s return. Meanwhile, Dr. Glassman gives Dr. Murphy some fatherly advice as they await news about Glassman’s recent tests.

Dr. Marcus Andrews introduces some of the team to a patient whose optimism and faith seems to cause Dr. Asher Wolke the most skepticism in light of his own relationship with religion.

Dr. Glassman and Dr. Murphy's relationship may be irreparably damaged following a tense moment during surgery. While Dr. Reznick struggles during her parental leave, Dr. Park may just be the one she needs the most.

Shaun and Lea are heading to the delivery room and everyone from the hospital is also there, except for one very important person. Meanwhile, a tragic accident involving Drs. Perez and Kalu pulls everyone away, including Dr. Murphy.

Shaun and Lea adjust to parenthood as they debate the importance of schedule and routine for Steve. Meanwhile, Shaun takes on his first case back at the hospital with two baby patients in need of the same heart.

Shaun struggles to accommodate the newest member of his surgical team, Charlie, who interferes in a patient’s relationship with his daughter. Elsewhere, Park tackles a tricky brain tumor, and Lea and Morgan adjust to motherhood.

Shaun continues to be tested by Charlie when their newest case prompts her incessant stream of questions – all in pursuit of an answer. Meanwhile, Morgan struggles on who to name as guardian for Baby Eden should anything happen to her.

Shaun and Lea struggle to balance their parental duties with their personal lives. Meanwhile, Park and Morgan try to find the time and space to reignite their romance amidst the demands of parenthood and work, and Lim's mother makes a surprise visit.

Asher's views on the construct of marriage complicate his future with Jerome. Meanwhile, Asher also briefly revisits his religious past to aid a patient's conversion to Judaism for his fiancée.

The team must deal with a mass casualty event that forces them to put aside their emotions following a recent tragedy.

Shaun and Jordan's patient is in dire need of a kidney transplant. When they find the perfect donor, they also discover that he believes he is Jesus which could compromise his ability to give consent to the surgery.

Shaun, Jared and Charlie's young patient need his parents to agree on an important medical decision that could greatly improve his health; however, his parents are unable to agree on the correct path which spurs the team to try and intervene on behalf of their patient.

Dr. Claire Browne returns from her work in Guatemala for a personal medical examination. Elsewhere, Dr. Glassman struggles to manage Hannah, who remains unresponsive to his attempts to help. Park seeks out the perfect last-minute wedding location.

As the doctors consider their futures, they work together to solve one of the most important cases of their careers.