Dr. Shaun Murphy has been assigned his first surgery by Dr. Audrey Lim. However, Dr. Marcus Andrews questions whether he is really ready. Meanwhile, as Dr. Claire Brown continues to avoid her complicated emotions about her mother, she and Dr. Morgan Reznick have a patient whose diagnosis has them doubting his story.

When a renowned surgeon comes to St. Bonaventure for treatment, the team’s enthusiasm is quickly overshadowed by the doctor’s behavior. After studying his case, Dr. Shaun Murphy sees a pattern he recognizes. Meanwhile, Shaun and Lea are forced to make a life-changing decision that will alter the course of their relationship.

Dr. Park and Dr. Murphy treat an elderly Asian man brought to St. Bonaventure by his daughter after being the victim of a hate crime. In addition, Lea goes behind Shaun’s back to help raise his negative patient satisfaction scores.

When someone mistakenly brings a hallucinogen-laced dish to the hospital's company potluck, much of the hospital staff and doctors are incapacitated -- leaving doctors Murphy, Glassman and Allen forced to take on all the hospital's cases, further exacerbating Dr. Murphy and Dr. Glassman's conflicting work styles.

The team treats a famous marriage counselor after she injures her ankle from falling, but when she offers relationship advice to them, Dr. Morgan Reznick quickly spots that their patient might be experiencing something far more serious. Meanwhile, Dr. Audrey Lim is determined to get to the bottom of what really happened in the OR during her surgery and sets off on her own internal investigation.

Shaun invites Aaron to stay with him while he has exterminators at his house and Lea realizes both men have a lot more in common than she realized. Meanwhile, Dr. Morgan Reznick wrestles with a big decision about her career and her personal life.

Shaun and Lea adjust to parenthood as they debate the importance of schedule and routine for Steve. Meanwhile, Shaun takes on his first case back at the hospital with two baby patients in need of the same heart.