In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives on the 100th episode.

When a woman pregnant with sextuplets arrives at the hospital, Dr. Marcus Andrews must split the doctors into teams to ensure their health and safety following their high-risk delivery. Meanwhile, Shaun and Lea must face their own hurdles as they discuss starting a family.

Drs. Shaun Murphy, Asher Wolke and Aaron Glassman meet a patient with an infected surgical sponge that was left in their abdomen. Meanwhile, Dr. Morgan Park must face her own past when she treats the victim of a sexual assault.

Dr. Shaun Murphy unknowingly creates a competition between Drs. Danica Powell and Daniel Perez when he introduces a new performance rating system; Dr. Morgan Reznick may have crossed a line with Dr. Alex Park.

Shaun and Lea soon learn that their surprise pregnancy may also come with additional complications. Meanwhile, Doctors Park, Reznick and Allen treat a teen with Gardner’s syndrome whose past surgical history jeopardizes the outcome of his current one.