Transplant patient and now doctor, Frankie starts her first day in Renal rotation; best friend Lou battles surgery's boys' club; and flatmate Tabb starts as an intern.

Frankie takes on the system to save a patient, and lands in trouble. Lou finds out it’s not always wise to have an affair with a boss; and Tabb questions his ability as a doctor.

On the eve of an investigation into a patient's death, Frankie realises that all doctors are fallible when faced with the reality of a health system that isn't always able to cater for all.

Chad Berger's days as a doctor are coming to an end, but he is determined to see through a complex set of paired kidney exchange transplants. Will he be able to do so, or will his own condition get to him?