Macy and Me join forces with Abigael to track down the Assassin. Maggie starts her new gig and has a breakthrough when she reaches out to help Jordan. Harry discovers a horrifying secret.

The Destruction of the Sisterhood looms large as the Charmed Ones face down The Faction. Harry and Macy are divided over a potential ally – Julian.

Mel and Maggie are learning to navigate life without their sister Macy. Mel distracts herself with new flings. Maggie takes on more than her share of demon hunting. Jordan teams up with Maggie while navigating his newfound magical powers.

Mel, Maggie and Kaela must divide and conquer when they become aware of a new, formidable threat inspired by the Tallyman. Maggie and Harry team up to chase down a lead in a dangerous magical realm. Mel needs Jordan's help healing a "creature" with whom she has a deep emotional connection. And Kaela's budding flirtation with Dev must contend with a surprise visitor from her past.

Mel, Maggie and Kaela, along with Harry and Jordan, have now discovered that the cabal of foes coalescing to bring down the Power of Three are actually working for an ancient evil that's been laying dormant since the dawn of magic. This powerful dark force – known as the Lost One – will be the ultimate test of the strength of the newly discovered sisterhood; forcing them to rekindle their connection...or face the destruction of magic itself.