One day, high school student Kaname Sudo's average life is interrupted by the arrival of an emailed invitation to join "Darwin’s Game." Without even thinking, he opens the app, thereby becoming a player in the game. Just as Kaname begins to suspect there's more to the shady app than meets the eye, his first battle suddenly begins, with a mysterious man in a panda suit lunging at him with a butcher knife. Will Kaname survive his first, desperate battle against a bloodthirsty killer?

Kaname and Rein discover that the Florist is watching their every move with the building’s surveillance cameras. They join forces to undermine his plans by destroying the cameras while evading his henchmen. Unable to escape the henchmen, they decide on a desperate strategy that leaves them with only a twenty percent chance of survival!