Dieci anni dopo che li abbiamo lasciati l'ultima volta, troviamo Bette in corsa per la carica di sindaco di Los Angeles; Shane mentre torna in città dopo una battuta d'arresto; e Alice che impara a bilanciare la co-genitorialità con la sua fidanzata Nat e l'ex moglie di Nat Gigi e il crescente successo del suo talk show. Incontriamo l'esecutore delle pubbliche relazioni Dani Núñez, la sua ragazza e produttrice televisiva Sophie Suarez, la loro migliore amica e coinquilina Micah Lee e l'affascinante ex nuotatrice olimpica diventata assistente, (Sarah) Finley.

Il clima di Bette ha continuato a ricadere mentre si prepara per un discorso del Centro LGBTQIA. Shane aiuta Finley, mentre Alice è infastidita quando la rete la costringe a portare un nuovo membro dello staff. Dani e Sophie festeggiano le buone notizie mentre Dani inizia un nuovo lavoro. Micah insegue una nuova cotta.

Bette prepares for an important mayoral debate. Alice lands a huge guest and encourages Nat to branch out. Shane visits a bar and gets embroiled in the lives of two of its employees. Dani and Sophie's families clash, Micah is unsure of where he stands with his crush, and a budding relationship forces Finley to confront some complicated aspects of her past.

Dani is forced to get involved in Bette’s personal life, Shane grapples with a big decision, Alice is profiled by a newspaper, Sophie worries that Dani is pulling back, Finley struggles with her growing feelings for Rebecca, and Micah still doesn't know where things stand with José.

Bette feels guilty about lying to Angie; some unexpected news throws Shane for a major loop. Alice, Gigi and Nat find common ground. Dani and Sophie deal with a bombshell dropped on them by Dani's father. Finley bonds with Tess and Micah grows closer to José.

Bette and Dani reckon with the fallout of a recent scandal. Shane spends the day with Angie. Alice, Gigi, and Nat have conflicting ideas about their family life. Sophie and Finley spend a raucous night out in an effort to get their mind off of things.

Bette is conflicted about old feelings, Shane is tested by her relationship with Quiara, and Alice gets blindsided at home and work. Meanwhile, with Dani busy with the election, Sophie feels relieved to have Finley around. Micah introduces José to his mother.

Tensions run high on election night as Bette and Dani await the results, Shane and Quiara go through their most difficult challenge yet, and Alice takes a big swing on her show. Meanwhile, Sophie and Dani consider another big step in their relationship, Finley is forced to stop running from her past and confront her feelings, and Micah is dealt an unexpected bombshell about José. Season finale