On 7 December 1987, Pacific Southwest Airlines Flight 1771, on a flight to San Francisco, crashes at the speed of sound on a mountainside in rural San Luis Obispo County, California. All 43 people on board are killed. Investigators found that passenger David Burke, a former USAir employee, took a gun on board the aircraft and shot the pilots in a murder-suicide plot to kill his former supervisor (who was also a passenger on board) after being fired from his job days earlier. USAir was in the process of merging with PSA at the time of the crash.

On 31 October 1996, TAM Transportes Aéreos Regionais Flight 402 crashes seconds after takeoff from São Paulo–Congonhas Airport into a heavily populated residential area, killing all 96 people on board and 3 on the ground. The crash was attributed to the uncommanded deployment of a faulty thrust reverser on the right engine.