Clark and Chrissy both notice a small crack in Lois' game face. Meanwhile, Sarah and Jordan have an awkward encounter. Lastly, Lana receives a panicked phone call.

Clark and General Lane are both having a hard time giving Lois room to make her own decisions. Meanwhile, Lana and Sarah have a run-in with an old friend at the diner. Lastly, Natalie has a surprise visitor.

Clark finds himself in uncharted territory, and Lois bonds with a new friend. Meanwhile, Superman pays Bruno Mannheim a surprise visit. Lastly, Lana puts Sarah in charge while she's away at a meeting with Chrissy.

Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis. Meanwhile, Matteo comes to Smallville to meet John Henry for the first time, and Sarah and Chrissy start to break the ice.

In the wake of learning that Bruno and Peia are married, Clark works to reignite Lois' interest in taking Bruno down. Elsewhere, Natalie meets Matteo's parents for the first time, with disastrous consequences. Meanwhile, the Kent boys clash when Jordan interferes with Jonathan's training at the Firehouse, Lana bonds with General Lane over their shared fear of dating again, and Sarah realizes her mom needs a friend.

Lois attempts to interview Peia in the hopes of unearthing the truth about an old case, while Clarke struggles to spend quality time with the boys. Meanwhile, Jonathan and Jordan find themselves at a party, where tensions between Sarah and Jordan come to a head. As Kyle's suspicions about a local meta-human grow, Lana must juggle her personal life with a visit from the governor. Finally, Matteo makes a life-altering decision.

Clark helps Lois prepare for a procedure but must leave the boys with her to help John Henry and General Lane track down the Mannheims. Meanwhile, John Henry and Nat butt heads over her desire to help Matteo, and Bruno's plans go awry as Peia's condition worsens.