A foreign submarine crew races Dr. Quest and his recovery team (aboard an American icebreaker) to a downed experimental missile in the Arctic ice cap.

A former archaeologist friend-turned Arab nationalist revolutionary named Ahmed Kareem, who is being stalked by a vengeful mummy, attempts to frame Dr. Quest and Race for the theft of a priceless Egyptian artifact.

While on an archaeological expedition to an ancient Mayan city in the Yucatán jungle, Dr. Quest is threatened by a greedy, ruthless British treasure hunter named Perkins and his native confederates, searching for riches in the same ruins.

In the Caribbean Sea, a new cook aboard the Quest research vessel betrays his employer to a gang of Mexican pirates (seeking a sunken treasure chest, discovered by Jonny).

On a visit to Japan, Dr. Quest finds that an old biologist friend (having gone insane) is breeding over-sized carnivorous lizards for the purpose of hunting human prey.

The Quest home compound in Florida is attacked by foreign (submarine-borne) agents, intent on stealing a new undersea crawling vehicle that Dr. Quest is developing for the United States Navy.

Jonny and Hadji are marooned (by shipwreck) on the jungle coast of the African continent, where they are adopted by a tribe of friendly brown gorilla-like apes who protect them from a pair of Australian poachers, intent on kidnapping them for ransom. When the poachers managed to abduct Dr. Quest and Race, Jonny and Hadji must persuade to the apes to help rescue them and defeat the poachers.