When Mitzi's flamboyant sister Lou comes to town, everyone is thrilled to see her -- except Mitzi. Jimmy tells his family about how his childhood was intolerable until he'd see his exciting, risque Aunt Lou for two weeks each year, and Mitzi is reminded about how her colorful sister always hogged the spotlight -- and her son. Now, Aunt Lou has offered to take Bonnie on a shopping spree to New York City, ruining Mitzi's plan to spend time with Bonnie. Thinking she is supposed to meet Lou at her friend Terry's loft, Mitzi finds herself the center of attention at ladies night out - Terry holds weekly support groups for a Transgendered support group. The ""girls"" show Mitzi more than just a better way to apply mascara, soon she sticks up for herself and confronts years of sibling rivalry.

Mitzi's old flame returns to town and heats up some sibling rivalry between Mitzi and her sister Lou and offers Jimmy pointers on how to be romantic. Meanwhile, Wendy has her first date.