Years before first entering the White House, Eleanor discovers Franklin’s marital indiscretions, which push her to socialize with more independent, politically active women in the salons of New York City. While Jerry rises through the ranks in Congress, a stubborn shoulder injury drives Betty to seek help from a doctor, who prescribes addictive pain medication. After toddler Sasha is rushed to the hospital with meningitis, Michelle vows to hold Chicago’s inadequate healthcare system to task by working to improve it from the inside.

Dissatisfied with Franklin’s complacency over growing international atrocities in Europe, Eleanor forces his hand to assist Jewish refugees fleeing Nazi Germany. Having retired to Palm Springs, Jerry plans to keep active across the country, which leaves Betty to seek out new party companions at home. Despite Barack’s political hesitations, Michelle refuses to stay quiet on racially driven violence any longer while writing her commencement address for Tuskegee University.

As Franklin helms the United States’ entry into World War II, Eleanor patriotically rallies the country as First Lady, which leaves Hick neglected on the sidelines. After Betty’s spiraling addiction reaches a breaking point, Jerry intervenes with the help of family and friends. When Donald Trump’s Access Hollywood tape ignites a national debate during the 2016 presidential campaign, Michelle joins Hillary Clinton on the campaign trail to advocate for the dignity of American women.