Kimball is working on a farm when he is captured by a sheriff and his deputy. The two men start fighting about how and when to turn Kimball over to the authorities-and one of them will go to any lengths to make sure he gets the credit for the capture.

Kimble arrives in a small town where women are being murdered by an unknown serial killer and a vigilante mob mistakes Kimble (a stranger in town) of being the killer. Kimble hides out with a young woman with learning difficulties named Joanne Mercer, a 'moon child' befriends Kimble and hides him in the basement of her house which is connected by a underground tunnel to a closed-down textile factory where the real killer is hiding out.

Kimble hops onto a freight train and finds himself in the company of three escaped convicts (two of which are wounded during their escape). One of the convicts dies from his wounds while the second one, a brutal murderer named Neil Pinkerton, forces Kimble to treat his leg wound. Pinkerton decides to keep Kimble as a hostage as a safeguard against the police. Pinkerton, Kimble, and the other prisoner, named Matt Mooney, seek refuge in a farm house owned by widow Mona Ross and her mother whom recognize all of them and treat Kimble, Mooney and Pinkerton as their celebrity guests.

Running from the police, Kimble hides out at a farm owned by a local country doctor, named Josephus Adams, whom treats his patients with little more than a dose of honey and a reassuring word. After one elderly woman under Adams care dies from a protracted bronchial infection, an angry Kimble intervenes and tries to help the patients. But in the meantime, Adams' wife, Marianne, stumbles upon Kimble's identity and tries to use that to her own advantage. When Dr. Adams teenage niece, Sharon, falls into a coma after having an alergic reaction to bee stings, Kimble risks his freedom to take her away from Adams to a hospital for treatment.

Reporter Barbara Webb spots Fred Johnson, the one-armed man, in a police roundup of suspicious character during a murder investigation. Calling to mind the Kimble case with her publisher boss Herb Malone, Barbara takes a photo of Johnson and publishes it in the local newspaper. The image of the one-armed man draws both Kimble and Gerard to the town. While Gerard waits for Kimble to show up at the police station, the fugitive is outside and sees Johnson in the jail courtyard. But the one-armed man spots Kimble and escapes from the jail and steals a getaway car. Barbara spots Kimble and tells him to get in her car as they chase after the one-armed man. During the chase down a winding mountain road, the one-armed man's car crashes, and Kimble has to tend to Johnson's injuries knowing that he's the only one to clear Kimble of his wife's murder. Unable to speak because of a head injury, Johnson nodds when Kimble asks if he murdered Helen. While Kimble rests, Barbara types a confession paper

After witnessing a small plane crash, Kimble rescues the pilot and two passengers, senatorial candidate Glenn Madison, and his assistant/secret lover, Pat Haynes. Glenn's PR man, Russ Haynes (Pat's husband) arranges for a sketch artist to draw a portrait of Glenn's rescuer whom had left the scene. Russ locates the fugitive and brings him to the Madison estate for Glenn to congratulate him for saving his life. But the sketch artist recognizes Kimble and calls the police whom arrives at the mansion. But Russ and Glenn hold them off. Meanwhile, Glenn's wife, Claire, recognizes Kimble, and threatens to turn him in unless he tells her of the person that Glenn has seeing, aware of her husband's long history of infidelity. But Kimble claims not to know anything. When Kimble confronts Pat, she admits to her affair with Glenn. Claire overhears the conversation and decides to destroy her husband's image. But Glenn murders her and then calls the police again to put the blame of the fugitive.

While working as a chauffeur in Denver, Colorado, Kimble reluntantly covers for teenager Lauire Ryder after she dents her father's car. But Kimble flees after discovering that Laurie was involved in a hit-and-run. After learning Kimble's idenity, Laurie's father, Dr. Mark Ryder, summons Gerard (along with the entire Kimble file) to Denver where he introduces Gerard to the 2130, a computer that can help capture the fugitive by determining a pattern to his travels. As the 2130 makes progress, Kimble's new travels all over the country end with one close escape after another with the police.

While working in a film supply store as a photo developer, Kimble spots Fred Johnson, the one-armed man, in a photo. After tracking down the freelance photographer, Howie Keever, whom took the photo, Kimble learns that Johnson works at a nearby chemical warehouse. Kimble goes to the warehouse and suprises Johnson. During the scuffle, Johnson accidently ignites some chemicals, chreating an expostion which leaves him badly injured and Kimble blinded by the flash. Johnson manages to escape and once again reports Kimble to the police. Kimble manages to escape from the hospital before the police arrive and tries to get back to Howie's apartment to ask him to hide him. But the police question Howie and his uncle whom learn Kimble's true idenity, as well as the $10,000 reward.

Kimble finds work at an upholstery store where the police are staking out the place in their search for an escaped killer, named Bowen. Kimble becomes aquainted with one worker, a Hungarian immigrant named Josef Karac, whom Kimble discovers that Josef is a doctor wanted by the police for an abortion that he performed years earlier. Meanwhile, the police stake out Dr. Karac's apartment where his wife, daughter and nephew live, while undercover cop, Jim Macklin, goes undercover as a worker at the shop where Bowen was last seen to investigate his girlfrend whom is Dr. Karac's daughter. But Macklin soon recongizes Kimble and begins a second investigation to try to capture him. In the meantime, Bowen returns and takes the Karac family hostage to force them to hide him from the police just next door.