Kimble is working as the caretaker at a spacious ranch in Connecticut which is owned by newspaper heiress Ann Guthrie who lives with her husband Harlan and her sister Ruth. Ann and Ruth's late father founded the Westborne Clarion, the newspaper that Harlan currently runs. Although Ann is the sole benefactor of her father's estate, she believes Ruth is entitled to part of the fortune. But Ann is unaware that the greedy Ruth is having an affair with Harlan and they plot to murder Ann and claim everything. When Kimble suspects Ruth and Harlan's plan and informs Ann, the skeptic heiress refuses to believe Kimble. Knowing that Kimble knows, the crafty couple plot to frame him for Ann's murder.

While working as a migrant worker in New Mexico, Kimble becomes an unwilling party to the kidnapping of a young boy whom is the son of his landowner boss. The boy, Jimmie, has been abducted by Ralph Simmons, a disgruntled former football player, along with his wife Helen and his cousin Dave. When Kimble discovers that Jimmie is a hemophiliac and that Ralph has bruised him during the abduction, Kimble must find a way to get the boy away from the kidnappers and to a hospital, or Jimmie will soon die from internal bleeding.

While working as a handyman in the predominantly Hispanic fishing village of Puerto Viejo, Kimble becomes aware that the area is beset with a plague epidemic and he's forced to call the state health inspector to have the entire area quarantined. But he soon finds himself trapped when the local doctor suspects his true identity and the irate villagers set out to find him.