Injuring after being shot during a police chase, Kimble seeks refuge at an orphange near a Navajo Indian reservation in Puma County, Arizona. Annie Johnson, the head teacher (and herself an orphan), removes the bullet and offers Kimble work as a teacher. Meanwhile, while the local sheriff Prycer belives that Kimble has escaped, a determined and overzealous deputy, named Steel, belives Kimble is still in the area and suspects Annie of sheltering the fugitive.

After being arrested in a small Montana town for a minor loitering charge, Kimble is put in jail next to a suspect in a race-related killing. A determined black deputy becomes determined to transport Kimble and the racist murderer to the state capital for arraignment. But their journey is filled with adventure and danger when they are ambushed by the killer's accomplices and are now forced to travel on foot through hostile territory.

Fleeing to Mexico, Kimble somehow contracts pnenmonia and seeks refuge at a local hospital where he is recognized by Dr. Howell, an ambitious American doctor whom is conducting reseach on menigitis. After Kimble recovers, Dr. Howell blackmails him into assisting with his research in exchange for protection from the local state police. While working with Howell's assistant, the attractive Reina Morales, Kimble soon discovers that several of the patients are being unwittingly infected and sacrificed for Howell's research purposes. Meanwhile, a persistent police sergeant, named Rodriguez, begins investigating Kimble's true idenity.