Ed Fraser (Howard Duff) returns to Medicine Bow, having served time for robbing the local lumber yard. He had been convicted based largely on Steve Hill's testimony but the stolen $30,000 was never recovered and his unknown accomplice, Helen Blaine (Ida Lupino), whose daughter (Joey Heatherton) Steve has been dating, had escaped. When there is what he perceives as an attempt on his life, Steve makes no secret of the fact he is convinced Fraser is out for revenge. When Fraser is killed Steve becomes the prime suspect. Although he avoids trial due to a lack of evidence, Steve becomes a social pariah and sees that the only way out is to solve the crime.

A bounty hunter named George Wolfe (Broderick Crawford) comes to Medicine Bow, having been summoned by a now dead informant who told Wolfe a fugitive is in town. Although the informant had left a letter revealing the fugitive's identity in a lock box at the bank it can not be accessed until the circuit judge can return and issue a court order. Trampas, who had accidentally become involved with some felons two years before, thinks he is Wolfe's quarry and Wolfe is suspicious of him. Before matters can come to a head, however, an outbreak of typhoid fever intervenes.

Former n'er do well Willie Caine (Albert Salmi) is now a monk, Brother Thaddeus. He is involved in establishing a mission and boy's school on property owned by Judge Garth and Trampas and Steve Hill are helping to build the mission. A gang, including a former crony of Thaddeus', robs the train and Sheriff Abbott (Ross Elliott) locks him up as an accomplice. Thaddeus manages to escape and with the help of Trampas sets out to track down the gang and exonnerate himself.