In 1968, 60-year-old Gwen Miller is brutally raped and murdered inside her own home. A devastating flood then halts the police investigation until ground-breaking science offers some new hope.

In 1963, the body of a toddler is discovered in the Keene Creek reservoir in Ashland County, Oregon, wrapped in a bundle of bedding. The child is determined to a white male, possibly having Down Syndrome. Despite the limitations of forensic science at the time, investigators are determined to find out who the so-called "Boy in the Bundle" is, and how he ended up in the water. After nearly six decades, developments in technology provide a major break in the case.