Marcellus gets a new partner, Aldo Rossi, and Mike has trouble adjusting to the change; after initially resisting Heather's suggestion that he reconcile with his father on his upcoming birthday, Mike finally relents, but his father rejects both his present and Mike; the ""Inquirer"" reporter who wrote the story of Mike's arrest now wants to paint him as a hero, much to Mike's disgust; when his friend Doug is killed in a hit-and-run accident after he gets out of his cab, Mike promises Doug's son Bobby that he will find the man who killed his father; after finding out that Doug had uncovered a fraudulent scheme at his company, Mike suspects that the company's chief financial officer had a hand in his death, and has mixed feelings when he is proved wrong by Rossi, who uncovers the real culprit.

Heather, Mikey and Grizz keep vigil as Marcellus and the rest of the force hunt down Johnny Scanlon, who has kidnapped Mike and threatens to execute him at the exact same as Johnny's brother Jimmy is executed by the state because Mike precipitated the incident many years before which led to Jimmy's killing a cop.

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Bettina's client Brian is released on a technicality after being accused of murder, and he seeks Mike's help in finding out who actually committed the crime so that his name and reputation can be restored; Marcellus undergoes surgery and gets good news from his doctor and a rebuke from Deborah for keeping his condition hidden; Liz helps Brian find a job and place to live when his employer and his wife abandon him; Jamie uses his street skills and some fast talking to provide Mike with an impressive vehicle in his search for information to support Brian's story; when he unearths information about the victim which reveals that she and her family were not who they appeared to be, Mike traps the murderer and clears Brian's name; as Mike arrives to take him home from the hospital, Marcellus is shot by a man posing as an orderly.

After Mike saves Leda Mills from three would-be rapists, she decides that the only way she can regain control of her life and prevent her attackers from hurting other women is to hunt them down and murder them; Marcellus helps a teenager being neglected and corrupted by his drug-addicted father; Mike is horrified when Leda phones him after the first murder to thank him for being her inspiration, and works with Marcellus to stop her killing spree, but it's Liz's insights into her behavior that give them the key to her capture.