Following the bludgeoning to death of a nurse, Hooker and co. investigate the case, the latest in a series of similar murders - a string of killings that Hooker investigated years before that has recently began again, in which the attacker sends a rose to the intended victim prior to the attack. With the aid of a disabled veteran detective and a top psychiatrist, Hooker and the team investigate and find evidence that the murderer, always dressed as an old-fashioned nurse, may actually be a man. But the pattern of the killings suggests that they have less than 48 hours to catch the killer before he / she strikes again...

Hooker and Romano by chance spot a van swerving dangerously over the road – in which a pair of teenage prostitutes are being held against their will by two men. When the van crashes off the road, they find one of the girls dead after being strangled – the latest victim in a series of killings by ""The Boulevard Strangler"" and his accomplice, who are prying on young runaways. Hooker finds that the surviving girl has run away after being abused at home, and leads a double life – a perfect high-school student, and as a prostitute. But now the girl is in danger with the killers after her, who are concerned that she can identify them in the murder of the other girl... Meanwhile, Corrigan considers leaving the force to take a job teaching...

Hooker and Romano are on patrol when their car is hit with a chemical based fire-bomb, which leaves Romano blinded. With Romano in hospital and facing permanent loss of sight, his girlfriend Maggie, a fellow Officer, takes his place as Hooker's partner as they investigate who was behind the attack and why. Unbeknown to them, a recently released convict, who's deceased cell-mate was put away by Hooker, has hired a chemical genius to wipe Hooker out, but the attempts on Hooker's life have deadly consequences for Maggie...

While on a stake-out to capture a strangler who is killing homeless women, Corrigan receives a blow to the head while struggling with a suspect, leaving him with a concussion which triggers sudden, unexpected bouts of enraged behaviour. But the suspect Corrigan took on isn't in fact the strangler, and with the real killer still on the loose, Hooker and the team must track him down before he strikes again. Corrigan's refusal to acknowledge his condition doesn't exactly help matters...

Responding to the latest in a string of rape muggings on women using automatic teller machines, Hooker finds that the latest victim is Episcopal female priest Beth Harrison, an old acquaintance. Although terrified, she agrees to testify when Hooker and the team nab the culprit, but the attacker cunningly goes to church to give confession about the rape to her, leaving Beth sticking to her sworn vow of silence over confessions and thus refusing to give testimony. Hooker tries to convince her to go against her beliefs and testify, or else the rapist will be free back on the streets and strike again...

After the third in a series of murders on attractive young blonde women, Stacy goes undercover to work as a salesgirl at a shopping mall store where each of the girls had worked, to act as bait to try and lure out the killer. With Stacy wired up, Hooker, Corrigan and Romano keep tabs on her until the killer makes himself apparent, but Hooker is concerned when the gun used in the murders suggests the killer to be a cop, and all indications point to the store's security officer being the culprit. But the operation puts Stacy in a dangerous position...

The shooting of a masseuse girl in Chinatown convinces Hooker that a Vietnamese crime mob is operating in the area and trying to take over the district's message parlours. With information from a Vietnamese girlfriend of Corrigan's, Romano goes undercover at the parlour in the middle of the trouble as an outcall driver, while Stacy works as one of the massage girls; but when Stacy's cover is roused, Hooker must race to save her...

Hooker's children come to visit their father, but the vacation is interrupted after Corrigan and another Officer unwittingly disrupt an armed race-track heist, which leaves Corrigan's fellow Officer dead. The robbers were under the pretence of being ambulance attendants, and Hooker has reason to believe that the robbery was an inside job; but the case means that his time with his cherished kids is limited...

While Hooker is investigating a violent supermarket robbery, his father, himself a retired police officer, arrives unexpectedly. Hooker is surprised at sudden arrival, and his father, who is in somewhat shaky health, ends up helping track down the supermarket robbery gang – but the one last case has a deadly outcome for the senior Hooker...

After an off-duty Officer is shot dead in a grocery store, Hooker – an old friend of the family's – promises the dead man's wife and son to find the culprit. A case in which the deceased Officer's partner sent a criminal to prison on a false testimony may be the key to the killing; but all the time, the killer has his next target in his sights... Meanwhile, Hooker looks into the recent murder of a local prostitute, only to discover that the two cases are linked...

Hooker becomes involved in an F.B.I. drug bust operation, a ""sting"" which leaves an undercover Detective critical in hospital, and the drug ring's middle man shot dead by the front man, who walks away with the $100,000 sting money. With the ploy following the same pattern as several previous identical ""rip-offs"", Hooker and a Federal agent join forces to put a halt to the big-time drug runner's scam, but their methods in putting the racket out of business clash...

When Hooker, Stacy and Corrigan aid in the stake-out of a money counterfeiting operation, Corrigan accidentally shoots dead an informant in the crossfire, while the head of the ring escapes. The shooting leaves a remorseful Corrigan questioning his choice of career, something that deepens even more when he is later forced to shoot a man involved with the counterfeiting ring who takes a hostage. The two fatal shootings leave the veteran Officer seriously considering leaving the force and taking a job offered to him by the woman he may choose to spend the rest of his life with. As the hunt for the counterfeiters continues, Hooker and Stacy try to convince him otherwise...

Arriving at the scene of the brutal murder of a college girl, Hooker recognises the method of murder as used by a serial killer dubbed ""The Night Ripper"", who was behind a spree of six grisly sex murders four years previously and was never caught. With the psychotic killer terrorising the city once more, Hooker is under pressure to uncover his identity and get him off the streets...

Corrigan and Stacy respond to a seemingly trivial call about an illegally parked vehicle, only to stumble onto an armed robbery of a check-cashing outlet. As Corrigan calls for back-up, Stacy intervenes in the robbery to stop a man from being shot, only to taken hostage by the trio of armed thieves. With Stacy held prisoner by the robbers, the head of the trio rapidly develops an ""obsession"" for her, much to the aggravation of his girl-friend, who is also one of the theives. As Hooker and Corrigan search for Stacy and the thieves, they risk taking on the might of City Hall when it becomes apparent that the father of one of the trio is involved in the Mayor's re-election campaign and is prepared to pull strings to keep the whole case quiet. Meanwhile, the trio's leader's obsession with Stacy continues to grow – and it is the only thing that is keeping her from being killed...

The pursuit and capture of a criminal reunites Hooker with Officer Karen Remy, whom have previously been romantically involved with each other, but soon after, Hooker is informed that Karen is dead after being shot in her car. With the murder having signs of being a professional hit, Hooker becomes determined to find the person responsible, and his prime suspect is Karen's Police partner. His disobeying orders by continuing to probe the killing sees Hooker suspended, but that's not enough for him to give up the hunt – but is there more to the case than he knows?...

While in pursuit of a pair of burglars who brutally attack anyone who interrupts their robberies, Corrigan pulls unconscious Stacy from their patrol car when it crashes, moments before it explodes. With the hunt on for the violent thieves, Stacy and Corrigan's ordeal brings them much closer together than ever before– something that begins to affect their working relationship, and sees Hooker injured due to their distracted states...

Hooker is delivering a captured criminal to the Federal court building when he meets Senator Grayle, an old friend; when a bomb intended kill the Senator explode. With Hooker having saved the Senator's life, himself, Stacy and Corrigan at the Senator's request travel to Honolulu, Hawaii, to work with the local Police department there and protect the Senator and his wife from the ruthless gangsters out to assassinate him. But in his time protecting the Senator, Hooker finds that he does not approve with many of his old friend's ways and methods; and it's a tangled web leading to finding just who is behind the threats...

After Corrigan drops Detective O'Brien's niece Jennifer off at a jewellery store to buy a gift for her uncle's 25th anniversary in the force, the store is hit by a pair of armed robbers, and in the robbery Jennifer is gunned down. With the only lead being the hi-tech gun used by one of the thieves, Corrigan feels responsible for Jennifer's death, and the investigation is hampered by a television news reporter eager for a story. Meanwhile, one of the murderous robbers gets a taste for the fame that the shooting brings him, and plans to make a play for the determined reporter...