After a U.S. defense department satellite crashes into the jungle, it's up to Sheena, Cutter and Cutter's old nemesis, Tyler, to track down and deprogram the satellite before the area is bombed by the military.

Cutter takes a group of tourists for the ride of their lives when they run into and are captured by a band of virus smugglers.

When an evil corporation tries to steal the land of the peaceful Souman tribe, Sheena helps them fight back.

When N'Gama's troops kidnap a young woman from Kali's village for him to marry, Sheena must don western clothing and infiltrate N'Gama's palace to rescue the girl.

When Tuma, the leader of the Kiptalamis, attacks a peaceful meeting between the leaders of the four tribes, Sheena discovers that he wants sole ownership of a sacred rock shared by the tribes and will kill any one who gets in the way of his destiny.

When a young friend of Sheena's is killed in a bombing, Cutter's old friend Tyler reappears to lead a mission to assassinate the terrorist responsible.

When a young girl and a government official die in a fiery car bomb, Sheena discovers a religious cult with murderous intent.

When a terrorist kidnapping threatens an important peace mission and stops the flow of a lifesaving vaccine to the village, Cutter's ex-wife is called in to negotiate.

Jealousy arises when Sheena's first love returns to Maltaka to open a long awaited school.