When a new Inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.

Daisy, Mack and Coulson race to protect Lincoln as Rosalind’s team hunts down the Inhuman in their quest for powered people. Meanwhile, Hunter proves that there is no line that he will not cross to exact his revenge against Ward and HYDRA.

Coulson and the team search for the Inhuman who is killing other Inhumans. Meanwhile, May feels that Hunter's mission to take down Ward is getting too personal.

The stakes get even higher as Hunter and May continue to go after Ward and HYDRA, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.

The S.H.I.E.L.D. team discovers dangerous truths about the ATCU, and Ward's plans to destroy S.H.I.E.L.D. take a surprising twist.

Ward's campaign for revenge brings the S.H.I.E.L.D. team to their knees, and Coulson proves he will do anything to settle the score.