As Chuck is beginning to adapt to his new life as a spy, a doctor who could possibly "cure" Chuck is murdered. Chuck then begins a high-speed fight for his life, all while trying to decide which of his two new colleagues might be out to get him. Meanwhile, Chuck's sister Ellie invites Sarah to dinner to meet the family.

In this Halloween episode Chuck meets a Federal agent just like him: A computer whiz whose brain is important to national security. However, Chuck soon has a personal dilemma arise when he has to decide whether or not to turn the man over to Sarah and Casey or to help him escape his handlers.

Chuck must learn to balance a real love life with his cover love life when he meets a charming young woman by the name of Lou. At the same time, his relationship with Sarah gets interesting when the duo must explain their sexual relations with Ellie and Captain Awesome on a double date. Meanwhile, there is trouble when someone is using truth poison in order to retrieve codes for nuclear facilities.

Bryce Larkin returns to town with news about Fulcrum. They have hired a wealthy software magnate named Von Hayes to decrypt information on a stolen chip containing a refresh to the Intersect with highly classified information. Bryce and Sarah have to pose as a married couple at Von Hayes' dining party to steal back the chip, while Chuck has to pose as a waiter. Meanwhile, Morgan has an encounter with the Mighty Jocks at the Buy More.

Christmas Eve does not go as planned when an amateur criminal on the run from the police crashes into the Buy More and takes Chuck, Ellie, Awesome and the rest of the Buy More gang hostage. In order to protect Chuck’s cover and the safety of the other hostages, Sarah and Casey secretly go in to the store to remove Chuck, but the mission quickly falls apart when Chuck refuses to leave his friends and family behind.

Chuck foils a plan to kill Tyler Martin, an international rock star. Chuck's night out with Tyler leads to trouble. Morgan holds a contest among his fellow employees.

Chuck foils a plan to kill Tyler Martin, an international rock star. Chuck's night out with Tyler leads to trouble. Morgan holds a contest among his fellow employees. 2D version of the Episode originally aired in 3D

Chuck's life seems to be coming together, his long-absent father has returned and he landed his dream job. Unfortunately for Chuck, neither turns out to be quite what he expected.

Ellie's big day finally arrives and Chuck must save her life and her wedding from being ruined by Ted Roark and FULCRUM.

As the upgraded Intersect, Chuck trains to become a full-fledged spy but hits rock bottom when he flunks out of spy school and loses Sarah in the process. Meanwhile, Morgan comes home from Benihana School to help Chuck get over Sarah.

When Awesome is mistaken for a super spy by the evil Sydney Price, Chuck must become his handler and show him the spy ropes. While on a mission for The Ring, they meet the mysterious Daniel Shaw. Meanwhile, Morgan gets promoted to assistant manager and must deal with Jeff and Lester's latest hijinks.

Chuck learns that his latest solo mission will be a final test to see if he is ready to be a spy. Chuck needs to put everything he has learned into action to avoid going back to his old life while Sarah and Shaw observe his every move.

While in Europe, Sarah and Chuck realize they’re traveling on a train with Spanish spies. Even though they’re all alone, they decide to take on these rogue agents. Of course, this impromptu mission doesn’t go smoothly. Meanwhile, Beckman orders her newest “unlikely” spy team – John Casey and Morgan Grimes – to track down the missing couple.

Shaw returns to threaten everything that Chuck holds dear as his friends, family and the woman he loves are all put in mortal danger. Chuck has to find Shaw and stop him before his own world gets torn apart.

Chuck and Morgan go on a rogue globe-spanning mission to find Chuck’s mom. Meanwhile, Sarah and Casey follow a trail to Russia as they investigate the mysterious Volkoff Industries and its operative, Marco. Back at home, Ellie delivers big news to her family.

Chuck and Sarah try to become better communicators as they join Ellie and Awesome on a trip to Costa Gravas; a forbidden romance may put Morgan at odds with Col. John Casey.

Afraid that his latest setback is driving a wedge between him and Sarah, Chuck resolves to prove himself by going on a dangerous mission with the overeager Agent Rye. Meanwhile, Morgan and Casey scramble as the "Buy Morons" attempt to uncover the true identity of Greta.

With the help of his old nemesis Alexei Volkoff, Chuck and the team hunt down a deadly weapon, The Norseman. In a pre-wedding surprise, Sarah springs a pre-nup on Chuck.

Chuck and Sarah put aside spy work to have a weekend of debauchery, but Awesome’s plans for Chuck’s big night don’t go quite as expected. Meanwhile, Ellie's investigation into her father's computer leads to a life-changing discovery.

Before he can kiss the bride, Chuck must enlist his wedding party to take down Vivian Volkoff and stop her from destroying the big day. When he turns to Alexei Volkoff for help, the CIA sends its toughest agent, Clyde Decker, to stop them.

Without the Intersect in his head or the support of the CIA, the world of espionage is a much more dangerous place for Chuck Bartowski and his team of freelance spies. To start, Carmichael Industries takes on a slick, rich thief named Jean Claude, and a conniving investor, Roger Bale, who has stolen money from some of the world's most dangerous people. Meanwhile, Morgan helps Chuck with a special surprise for Sarah. Back in the Buy More, Jeff and Lester have taken things to another level with their latest scheme.

Chuck enlists his family, friend and some unexpected allies as he races to stop Nicholas Quinn from destroying everything Chuck has built over the past five years.