House and his team have to act fast when a high school student is admitted with a mysterious and lethal poisoning, especially when they discover more teens have been diagnosed with the same deadly illness.

Dr. House's young patient believes his illness is the result of a curse while House uncovers important information about Chase's father.

House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.

Cuddy struggles with a case of guilt when her handyman is injured while at her place, and House and his team have to work fast to save the young man's pursuit of the American Dream.

House takes the case of a man who experienced a seizure but wasn't aware it happened. When the man suffers a heart attack and needs a heart transplant, the team races to diagnose a dead woman's illness so they can harvest her heart to save their living patient.