Wilson prepares to transplant bone marrow from Matty to his brother Nick. But when Matty gets sick, the team must cure him as he's the only safe donor. Meanwhile Foreman deals with the consequences of his mistake and House has a battle of wills with his new pet Hector.

A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart attack prior to a serious plastic surgery.

House and his team have to diagnose a case at a distance when a researcher at a South Pole base is taken ill.

House is convinced one of the actors on his favorite soap opera “Prescription Passion” has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House’s assessment and do not believe there is anything wrong with him.

The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.

House and his team deal with a bullied girl who collapses during her school's Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington's disease drug trials, House gives a patient a gift, the staff wonder who gave House a special gift, and Cuddy gets an unexpected gift.

House and the team take on the case of a ballerina whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only the prospect of never dancing again but also of dying an agonizing death. The team must use their imaginations to carefully choreograph ways to test and treat her delicate body without killing her. Meanwhile, House continues to suffer from what he thinks is insomnia, and he is willing to go to desperate measures to cure it.

When a controversial African politician falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House’s prying exacerbates the problem.

After House’s medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick, an adult film star admitted to Princeton Plainsborough for pulsating eye pain. Meanwhile, Cuddy is reminded that Princeton Plainsborough is not conducive to healthy personal relationships.

House and the team rush to treat an ailing college football star in time for the patient to compete in NFL tryouts. But when the patient experiences an onslaught of varied and unusual symptoms, the team has trouble reaching a consensus on how to effectively treat him in time. Meanwhile, Foreman’s brother Marcus makes a surprise visit to the hospital.

During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.

House and his team make unexpected discoveries about a female patient admitted to the hospital after severe and uncontrollable vomiting; House and Cuddy are forced to face the reservations in their relationship after a visit from a massage therapist.

House and the team try to link symptoms of a teenage military recruit and his drill sergeant, while House secretly helps Cuddy's daughter get into a prestigious preschool. Someone posted a disparaging photo of Chase on a social-networking site.

The team takes on the case of a lottery winner (Donal Logue) suffering from paralysis and multiple types of cancer, and they must figure out if it his new millionaire lifestyle that is making him sick. Meanwhile, Cuddy's mother threatens to sue the hospital over her treatment, and Foreman and Chase make a bet over who is repressing the uglier side of their personality more.

A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder.

House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily "companionship," House teams up with his "wife" Dominika to sabotage Emily's budding relationship.