It's Valentine's Day, and Cuddy has a blind date. Meanwhile, House leaves ER duty to take the case of a child patient named Hannah.

House treats a 16-year-old chess prodigy who gets everyone on the team annoyed with his behavior. Foreman is upset with House because he thinks his boss sabotaged his job interview with another hospital.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.