After Charlie and Nora rescue Miles from Militia, they set off to meet Aaron and Maggie. Tracking Miles and Charlie at every turn is Nate. As the gang reunites and continues on their journey, unforeseeable challenges await.

When Charlie meets a boy who's suffered a plight similar to her own, she relates and longs to help him and his young friends. First, she must convince Miles. Meanwhile, Rachel grows weary of General Monroe as she meets someone from her past.

In the gang's quest to rescue Danny, the time has come for Miles and Monroe to meet face to face. Meanwhile, on the verge of reuniting with her brother, Charlie is conflicted by a shocking discovery and Rachel tests Monroe's patience.

Neville faces danger and hard choices as Monroe doubts his loyalty, he disowns his son Jason and gets captured by Miles. Rachel and Charlie begin slowly patching their relationship only to be pulled apart again as Rachel suddenly embarks on a quest to restore the power and her self-respect. She must make a dangerous journey to the mysterious Tower as it holds her only chance at redemption.

Miles and Tom Neville find themselves fighting for the same cause but Miles still doesn’t trust him. Charlie, Jason and Nora attempt to pull off a daring river rescue of Dr. Stephen Camp to keep deadly anthrax out of the hands of Monroe. Meanwhile Rachel and Aaron are captured and threatened by Militia forces.