A captive Nora is tortured and left for dead. Monroe learns of Rachael’s attempt to reach the Tower but is unaware of her deadly plan for him. Meanwhile, Miles is desperate to find out how so many of his close associates are being brutally murdered. Later, Miles, Charlie, Neville, Jason, Hudson and Sanborn struggle to make it out of the Plains Nation to join Rachel and save her from what they believe to be certain death.

Miles's life is in grave danger as he finds himself in the clutches of Titus Andover. Charlie is determined to find Monroe, as Rachel and her father, Dr. Porter desperately attempt to revive Aaron. Meanwhile, Neville hatches a plan to infiltrate the Patriots.

Aaron and Rachel speculate on the extreme effects of Nano technology, while he also confides in Cynthia. Meanwhile a figure from Miles's rugged past, Texas Ranger John Fry reemerges. Fry could be Miles' chance to bring down the Patriots in a big way, however Fry will need convincing. Charlie has a surprise for Miles and her mother, while Secretary Allenford holds a secret important to Neville.

As Miles and the gang try to escape the perils of their current situation, Rachel and Gene continue to struggle with their relationship, which affects Charlie. Meanwhile, Neville takes a gamble with the Patriots.

Monroe finds himself in unfamiliar territory and must make a choice about his son Conner, while Neville and Julia continue to tango at Jason's dismay. Meanwhile, Gene leads Charlie to an uneasy discovery.

With their lives in danger in New Vegas, Monroe and Connor face a difficult decision in order to survive. Back in Willoughby, Miles questions whether he can trust Neville and Jason to help take down the Patriots. Meanwhile, Aaron and Priscilla find themselves at odds over the nano code.

While Dr. Porter and Miles venture into Willoughby in search of allies within the town, Monroe seizes an opportunity to surprise the Patriots. Neville’s political maneuverings put him and Jason in serious danger, as Aaron and Priscilla continue on their journey.

Truman, empowered with new authority from the President, launches a mustard gas attack designed to kill Miles and Monroe. To Rachel's disappointment, Miles agrees to join Monroe in a ruthless plot to beat the Patriots at their own game. As Neville faces his own challenge from the Patriots, Aaron grows increasingly alarmed by the power of the nanotech.