A mysterious woman who organizes illegal, high-stakes poker games arrives on Holmes and Watson’s doorstep and tells them her life is in danger claiming to be a former associate of Mycroft, Sherlock’s brother. However, as the pair investigates, Joan becomes suspicious that their new client isn’t being truthful.

When Shinwell comes to Holmes and Watson for help after he’s framed for a gang killing, they have three days to find the real murderer before he is arrested and sent back to jail.

Holmes and Watson investigate the murder of a man Sherlock considered one of New York’s worst private investigators. Also, as Holmes stews over being beaten by Shinwell, he decides to take out his aggression by dismantling a local organization of private investigators.

Holmes and Watson’s search for the killer of a woman found encased in cement takes them inside the clean technology industry. Also, Watson takes a giant leap forward regarding her interest in adoption

Holmes and Watson discover that the murder of a robotics engineer may be connected to his groundbreaking secret research in the area of real-life teleportation. Also, when Detective Bell is shut out of a required class he needs in order to complete his master’s degree and join the U.S. Marshal Service, he is shocked to discover the course instructor has personal reasons for denying him access.

Holmes and Watson race to locate a missing woman when Harlan Emple, Holmes’ friend and “Irregulars” mathematics expert, becomes the prime suspect in her disappearance.