Owen stresses teamwork and moves his leadership role over to the baseball field when he signs the doctors up for a baseball league, pitting them against their biggest competition, Seattle Presbyterian; Lexie tries to hide her jealous rage when she sees Mark with a new woman, but her emotions get the better of her; Alex fights to keep Zola at Seattle Grace after it is suggested that she be moved to another hospital due to a conflict of interest with Meredith and Derek; and Richard scolds Meredith and Bailey for their feud

In the spirit of Valentine's Day, Meredith and Derek try to have a night to themselves when Lexie offers to watch Zola; Callie hands babysitting duties over to Mark so that she can surprise Arizona with a romantic evening; and Ben proves to Bailey that he knows her better than she thinks. Meanwhile, the ER fills with romantics, including a 10-year-old girl who has an allergic reaction to chocolates from her valentine and a man who is hit by a car while chasing down his frustrated girlfriend.

In this Meredith & Cristina-centric episode, the two friends continue to cope with life after the plane crash and their ever-growing responsibilities at their respective hospitals. As Meredith juggles taking care of Zola with a case that hits close to home, Cristina assists Dr. Thomas on a challenging heart surgery.

As Derek and April work around the clock to find a solution for the hospital, Cristina struggles to respect the wishes of a family whose son is dying. Meanwhile, Arizona empathizes with a teenager who faces problems similar to her own.

Meredith struggles to balance her roles as a surgeon and a mother when she returns to work; Stephanie tries to impress Jackson's mother; Jo becomes overly involved with a patient.

It's Richard's birthday and Bailey invites him to scrub in on the case of a lifetime. Meredith hires a research assistant to help with her portal vein project. A scorned Callie gives Derek quite the shock. Meanwhile, Shane helps screen candidates for Cristina's clinical trial and meets a young expectant mother who needs his help.