Meredith works on a patient who happens to specialize in matchmaking, and a seemingly drunk patient pushes Richard's buttons and gives him a medical mystery to solve. Meanwhile, Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming as she struggles with issues in her own personal life.

Maggie introduces mood rooms as an alternative approach to medicine. Alex and DeLuca butt heads over an 11-year-old patient who tries to sabotage her own surgery. Jackson and Richard deal with a gender non-binary patient. Meanwhile, Teddy has a pregnancy scare that brings Owen and Koracick to odds.

After Meredith inadvertently stirs up negative press for Grey Sloan, she tries to make things right with her former colleagues, jeopardizing her community service hours. Station 19’s Ben and Vic bring a young woman into the hospital, and Jackson stands up to Koracick when he goes too far with a patient’s family. Meanwhile, Bailey receives unexpected news; and Owen finds himself at Pac-Gen North, which Alex sees as a recruiting opportunity.

A wealthy inventor arrives at Grey Sloan and asks Koracick for help, while Meredith struggles to save a woman with diabetes who has been rationing her insulin. Jo and Link fight to save a young man who fell onto train tracks, and Jackson and Vic's relationship hits a snag.

Owen and Link treat an older woman who wakes up from surgery and can’t stop singing, while Teddy helps Koracick stay afloat after an estranged loved one from his past comes to the hospital looking for help. Meredith, Bailey and Maggie focus their efforts on a difficult patient with a tricky diagnosis.

Bailey panics as she hears there has been a surge of COVID-19 cases, knowing she has loved ones in an assisted living facility. Meanwhile, Jackson and Richard team up against Catherine to teach her a lesson, and Teddy continues to try to mend her frayed relationships. After an intense surgery, Jo is uncertain about her future.

Amidst the need for more surgeons, Jo tries to convince Bailey to let her switch specialties. Elsewhere, Link accuses Amelia of overstepping while he is treating a patient remotely, and Winston comes up with an out-of-the-box idea.

Levi gets accepted into the vaccine trial. Meanwhile, Amelia and Owen treat a car crash patient, and Hayes and Jo are met with Luna’s legal guardian.

Richard recruits Meredith and Bailey to help him launch a new program. Meanwhile, Addison’s patient has complications from a procedure, and Jo helps a woman who goes into premature labor.

The doctors celebrate the holidays; Hamilton and Meredith prepare for a milestone on their project; Link wants to spend the holiday with Amelia and Scout as a family; Schmitt is faced with a difficult decision during surgery.

Bailey faces an unhappy Catherine who is facing audits for several of her Foundation hospitals. Meanwhile, Addison is back at Grey Sloan; tensions rise between Meredith and Richard, and Owen returns to work.

On the heels of life-changing news, a thunderstorm hits Grey Sloan. The attending surgeons and interns work together to save an injured reporter and family affected by the storm. Meanwhile, a beloved author undergoes a risky surgery, and complications from the storm arise.