Meredith and the team are focused on helping Owen’s sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital.

Meredith struggles to come up with a new plan for Owen’s sister. Jo makes a surprising choice regarding Alex, and Andrew’s sister’s controversial research leads to a shocking discovery.

Harper Avery arrives at Grey Sloan, putting Bailey on edge. A familiar face from Meredith’s past returns as a patient, and Amelia tries to manage a secret.

Amelia confronts a difficult situation, while Meredith deals with the fallout from her conversation with Nathan. Maggie finds herself at an awkward family dinner, Jackson receives big news, and Richard and Bailey search for the stars of tomorrow.

In a flashback to Iraq in 2007, the events leading up to Megan’s kidnapping are revealed. In present day, Owen and Megan hash out old wounds.

Owen and Teddy have to deal with the surprise arrival of Megan Hunt, who knows nothing about their situation. Catherine preps for her first surgery back on a war veteran who’s not emotionally prepared for his procedure. Meredith worries about DeLuca operating alone with Richard.

As the city of Seattle revels at the Phoenix Fair celebrating the city’s rebirth post-COVID, the Grey Sloan doctors treat a patient who encounters illegal fireworks. Meanwhile, Bailey has her sights set on hiring new doctors, but she’s having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement, and Meredith has a surprising opportunity when she meets a dynamic doctor from her mother‘s past.

The crossover starts on Station 19 S05E01 Phoenix from the Flame (I).

Meredith seeks advice from Amelia. Meanwhile, Richard is reenergized as he takes teaching to a new level at the hospital, and Winston treats a patient suffering from kidney failure.

Richard recruits Meredith and Bailey to help him launch a new program. Meanwhile, Addison’s patient has complications from a procedure, and Jo helps a woman who goes into premature labor.

The Grey Sloan doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. Owen experiences PTSD after he hears the explosion, while his sister Megan enlists help from Winston and Hayes in confidence. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

The crossover starts on Station 19 S05E05 Things We Lost in the Fire (I).

It's Thanksgiving, and while Meredith faces travel complications due to the weather, Nick steps in to help in more ways than one; Richard and Bailey seek out emergency surgeries; Amelia and Link reconnect.

The doctors celebrate the holidays; Hamilton and Meredith prepare for a milestone on their project; Link wants to spend the holiday with Amelia and Scout as a family; Schmitt is faced with a difficult decision during surgery.

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own; Meredith works to save Dr. Hamilton's life. Levi is impacted from his latest loss.

Schmitt must face the Morbidity and Mortality conference. Meanwhile, Meredith convinces Nick to scrub in on a surgery in Seattle, and Jo faces her feelings.

While Richard ponders his surgical abilities, Jo is charmed by her patient’s brother. Elsewhere, Megan makes sure Teddy and Owen talk out their differences, and a pet python causes an uproar.