A man is killed after winning a fortune and then dumping his girlfriend. So, Grissom, Nick, and newcomer to the CSI team, Sara Sidel, investigate this one. Holly Gribbs is in the hospital and Warrick is up for suspension for leaving her at the crime scene by herself. Holly later dies in the hospital, but Grissom doesn't suspend Warrick.

Grissom, Nick, and Sara search for a kidnapped woman and find more than they expected. Catherine and Warrick investigate the hit and run death of a little girl.

Grissom and Catherine investigate when a leg is found severed from a body in a lake. They suspect the husband and boyfriend. Meanwhile Sara and Nick investigate a fraternity pledging gone terribly wrong.

Grissom and Warrick take the case of a young man who is found naked in the desert without an obvious cause of death. Sara gets to find out why the body of a woman who was buried last week is in a dumpster. Catherine and Nick investigate the killing of a school's dean by the school's founder.

Grissom and his team investigate the death of a first class passenger on a flight to Las Vegas. The investigators are forced not only to examine the physical evidence, but also to interview all of the first class passengers to get their personal accounts of the incident.

A woman is abducted from a supermarket. In the store, Grissom finds a bathroom stall door that claims five women have been killed. Warrick is caught in a casino on duty and is paired with a reluctant Sara. Their case is the apparent murder and robbery of a man who is found be his brother. Nick gets pulled in by his prostitute friend who gets in a scuffle with hotel security.