A 28 year-old single mother is found dead. Initially, it's believed to be a suicide, but Catherine determines she was murdered. Also, Ecklie summons Grissom to refute the testimony of an entomologist in a murder trial.

The CSIs sift through the overwhelming evidence from a shootout with drug dealers in order to determine who is responsible for the death of a police officer killed during the incident.

The CSI's are called out to investigate the disappearance of a boy whose father died four years ago. Soon a couple is arrested at a convenience store with a boy matching the description of the missing kid. The only problem is they both claim it is their son. Both parents have exactly the same picture of the boy, with a scar on exactly the same place on his face. They hope a DNA-test could confirm who the real parents are, but when this information comes to light, it lead to another bizarre twist, possibly murder.

The CSI team investigates the murder of a man suffering from a congenital hypertrichosis, causing him to grow excessive body hair. Elements of the case suggest a connection with a belief in werewolves. The case leads to the victim's sister, who suffers from the same disease. Because of her condition, she'd been hiding from the world, but it turns out that she's hiding facts that are vital to solving the case.

The CSIs investigate the stabbing of a motocross racer who was about to leave town with a young woman he had been living with. Also, Nick comes closer to finding the truth about his kidnapping.

The CSIs investigate the gruesome murder of Lady Heather's estranged daughter, Zoe, who was found in the middle of the Vegas desert.

The investigation into a body found in a chimney leads the CSIs to re-open an investigation of an unsolved homicide of a female teenager named Caroline Fitzgibbons.

The CSIs become the focus of a reality TV series, which follows them while they investigate a serial rapist, who recently gained access to a woman's apartment by posing as a fireman. Also, Warrick's work on the late-shift is causing problems with his marriage to Tina.

The team investigates the death of a psychic who "saw" her own death while performing a reading for two other women. Greg reveals a family secret to Grissom but Grissom believes that science will be what solves the case.

A wealthy defense attorney is killed at her son’s wedding but Nick’s car, containing all the collected evidence is stolen and the case is compromised. After discovering new evidence, the team suspects that someone from the wedding party may be responsible for the murder.

A man accused of murdering his wife and co-workers leads the CSIs on a wild ride through a busy casino, eventually barricading himself and a hostage in a casino hotel room. The CSIs process the evidence from the crime scene to determine whether or not the man acted alone or had an accomplice. One of the CSIs eventually steps in as a hostage negotiator, putting himself in danger.

In the season finale, the CSIs wait by the bedside of one of their own when he's shot in the line of duty. One CSI faces a hard choice by having the power of attorney over their injured friend and colleague. Meanwhile, the team also investigates the strange way of life of one man when he is found decapitated by a train.

In the second part of this two-parter Grissom investigates the murder of an aging rockstar who is found dead in his kitchen with an exact replica of the crime scene on the counter next to him. Meanwhile, Catherine probes her own abduction and learns that someone may be targeting her family.

Identical twins are found murdered on the same night. The CSI’s investigate the two separate murders only to find a twist in the investigation find that leads them in another new direction.

Nick and Keppler investigate the bizarre world of the black market sales of body parts after they find a body that has been burned and the organs removed. The rest of the CSI team investigates the death of rich woman who was killed in her own home.

Grissom returns from his sabbatical; Keppler is put into a compromising position when the bodies of a Trenton police officer and a hooker are found in a hotel room. The man who found them is a retired New Jersey cop and close friend to Keppler, who doesn't reveal their relationship.

Grissom and his team are discouraged when they find a pool of blood as they begin investigating the disappearance of a high school basketball star and his cheerleader girlfriend.Grissom's quip that the young lovers may have run off to Mexico is soon quashed by the discovery of drops of blood by Ryan's vacant parking spot at the school. After finding a letterman jacket and cheerleading sweater in the field house and a pool of Ryan's blood nearby, the team tries to determine what went awry.

After a man is killed in his limousine, Greg finds that the murder victim has ties to the man he had to kill in self-defense. The team finds that the brother is involved in this investigation and has to deal with him and his hostile mother.

The CSI labrats take center stage to discuss the case of the Miniature Killer.

Grissom investigates when a sadistic client tries to murder Lady Heather (Melinda Clarke), who makes the probe more difficult when she refuses to name her attacker. Also, Grissom's reunion with Lady Heather makes Sara uneasy.

As the CSI's continue their search for and discover the identity of the "Miniature Killer", Grissom and Sara's relationship gets exposed to the rest of the team as she goes missing during the investigation. The "Miniature Killer" is finally captured, but not before a member of CSI becomes the killer's final victim.

The team investigates a girl whose whole family had been killed and she is supposedly possessed by the devil.

Grissom investigates the mysterious hanging death of a young man whose body looks like that of a female.

Grissom and his team investigate when an actress is killed on the set of a horror porn film.

Grissom and the team join forces with Jack Malone, an FBI Agent from New York to track a serial killer.

The crossover continues on Without A Trace S06E06 Where & Why (II).

Hodges stages hypothetical murders in the lab in order to give his fellow lab techs a chance to play CSI, but unbenownst to them he has other motives behind his actions. Meanwhile, after Sara's farewell, everyone tries to comfort Grissom.

The world of illegal dog fighting is explored by Grissom and the rest of the team when they take on the case of a wealthy socialite who was murdered. Meanwhile, Warrick struggles to clear his name in the recent exotic dancer murder case.

Two murders that happen during Las Vegas' annual bull riding rodeo are investigated by the CSIs, who find that the murders might be connected to illegal bull breeding.

CSI investigates the death of a little girl whose identity remains unknown.

Brass, Catherine, Grissom and Nick work the case of a female victim found in an apartment building with a gun shot wound. Drops becomes a person of interest during the investigation, even though he is still in jail.

A deer is illegally killed, and the person found with the body in the back of his truck apparently dressed it in a tutu. The man, who was completely drunk when arrested, was being interrogated by Nick and Brass, and suddently tries to escape and is pepper sprayed. Unfazed by the spray, officers then taser him and he bursts into flames and dies. Meanwhile an unbalanced woman wearing a tinfoil outfit at the front desk tries to warn people (including Nick) of an alien invasion. After observing the burning man, she later turns up dead with green-tinted blood. When other people turn up with the same problem, it's up to the team to figure out why. Meanwhile, an old couple dies, apparently in their sleep... but there is evidence the cases are related.

Catherine comforts Warrick when he is accused of murdering a famous Vegas gangster and even he is uncertain of his guilt or innocence.

After Warrick is shot in a Las Vegas alley, the CSI team comes together to deal with the aftermath.

A hypnotist bank robber becomes the prime suspect in a murder investigation.

The team investigates the death of a woman who turns out to be the daughter of a wanted criminal.

Grissom asks Lady Heather for help when the team investigates a case connected to the world of domination.

The team has a hard time investigating a shooting in Koreatown when none of the witnesses will talk about the crime.

A popular young singer is found dead outside an infamous Las Vegas nightclub, leading the CSI team to uncover a link between that crime and a murder 50 years earlier.

When the team discovers a connection between a new murder and a serial killer, Grissom secretly joins the class of a criminal pathologist (Laurence Fishburne) to help crack the case.

The CSI team is shocked and saddened when, after working with Dr. Raymond Langston (Fishburne) on the "Dick & Jane" murders, Grissom announces that his time as a CSI has come to an end and offers Langston a permanent position on the CSI team.

The first day on the job for Dr. Langston turns from bad to worse when a simple burglary case quickly overlaps with a complicated arson and homicide case.

The detectives search for the murderer of FBI agent Billy Ray Jackson, only Billy Ray isn't really an FBI agent, and neither are his impressively capable partners, Miles Baker and Emma Solomon.

Langston and Nick are called to investigate a murder at a fast food restaurant and have quite a task ahead of them when they discover that much of the evidence is coated in cooking oil.

The CSI are called to three different crime scenes in one night that are seemingly unrelated, but each case's forensic evidence reveals a common link

Langston and Riley are taken hostage during the aftermath of a shootout in an usually calm Las Vegas community.

Langston is shocked when his former student is found murdered and becomes the focus of a CSI investigation into the world of Mexican wrestling.

When a seasoned sky diver is paralyzed after free falling to earth when his parachute doesn't deploy, he turns out to be linked to the strange death-by-airborne-toxins of two wealthy men with ties to Iran.

When the producer of the reboot of a classic SF show is murdered at a Las Vegas science-fiction convention attended by both Hodges and Wendy (both, unknown to each other, fans of the original show), they find a connection with each other as the team investigates the crime.

Catherine revisits one of the very first cases she worked as a CSI when the convicted felon in the murder claims the verdict was based on faulty evidence.

A series of indeterminate deaths test the deductive powers of the CSI team, who fear that a public health emergency may be in the offing. Meanwhile, a friendly rivalry over who will win an upcoming bikini contest takes a deadly turn...

A band of vicious bikers is given the go-ahead to take down one of their own when it's discovered that the guy is an undercover cop.

A cache of missing chips from a closed down casino turn up in Vegas and a string of murders follow, leading Langston to use deadly force for the first time in his career as a CSI.

A rising young star is killed in a wreck and her determined stalker claims credit, but the team finds out there's more to this tragedy than meets the eye.

The son of a notorious killer is arrested on suspicion of murder, and the CSI team must overcome their natural prejudices against the boy's antecedents in order to track the true culprit.

The team investigates the murder of Jason, a troubled computer geek working at a low-level casino support industry job who lures a colleague, Paulie, into a dangerous plan to make a working stiff's dream come true.

When a policeman kills another officer, the CSIs must look to the evidence to determine if the shooting was premeditated or an accident.

After a beloved college football coach is found dead and his house drenched and spattered with his blood, the CSI team hunts for the killer who didn't find Coach Jimmy lovable at all.

When two seemingly different crimes turn out to be related, the CSIs discover they're interlocking parts of the same revenge plot.

The CSI team helps Ray Langston investigate a prostitution ring that may have harbored a hostage he has been looking for in Miami and New York.

The crossover starts on CSI: Miami S08E07 Bone Voyage (I) and CSI: New York S06E07 Hammer Down (II).

A bowling tournament is disrupted when an important piece of evidence is uncovered, leading the CSIs to investigate a murder at the same bowling alley.

When Nick, Greg and Hodges take Henry to celebrate his birthday at a biker bar, they uncover a double homicide and find several suspects still at the bar who may be the murderers.

The CSIs dig to find the truth about how a recent shootout at a gun store might connect to a young woman who may have committed suicide.

Two secretaries on holiday from Arizona attempt to steal a man's wallet and ATM pin number in a scam, and wind up dead in different locations. Meanwhile, the CSI team also investigates a disturbing medical mystery involving the dumping of human organs in a wildlife refuge.

The CSI investigates the mystifying death of a former pro golfer whose allegiance to the game might have cost him everything.

The case of two high school students, one dead and one missing, lead the CSIs into the underbelly of streetcar racing and a tangled web of deadly competition.

When a band member of Rascal Flatts is electrocuted by his own guitar during a concert, the CSI team investigates if it was a case of foul play.

When a young boy is found murdered, the CSI team uncovers evidence that may link his death to an old case that recently resurfaced.

Catherine and Detective Vartann are thrown together in a hotel room for 24 hours as they stake out a duo making drugs in the room next door. Meanwhile, Nick and Langston work a case that involves a fetish which has become big business in Vegas.

When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.

When Hodges and Wendy take a group of high school CSI Explorer Scouts on a field trip, they embellish their role in solving cases and take their assignment a little bit too far.

When a student is discovered murdered at Lindsey's school, the investigation takes a sharp turn when the CSIs uncover an unlikely connection between the boy's death and atrocities of the past.

A legendary comic from the good old days of Las Vegas is set to reunite with his partner on stage for one night only, until one half of the famous duo is found dead.

A mother thought to be grieving for the loss of her family three years ago becomes a suspect in a CSI investigation.

The CSI team must investigate one of their own when Langston is accused by a former colleague of being part of the Dr. Jekyll murders, on part one of a two-part season finale of CSI.

The CSI's lives are on the line as they close in on the elusive Dr. Jekyll, and more than one member of the team may not live to see his capture, on part two of a two-part 10th season finale of CSI.

The team investigates when a woman is attacked by a shark in the pool at a Las Vegas casino.