It begins with New Gotham in chaos. In one night, Catwoman is murdered and Batgirl falls in a rain of gunfire, victims of The Joker's wrath. With his true love dead, The Caped Crusader flees the city and Batgirl, now confined to a wheelchair, redefines herself as "Oracle", a master of cybernetics and weapons design. She takes under her wing the secret daughter of Batman and Catwoman, "Huntress", who is as fierce as she is beautiful. Powerful, haunting visions lead a third young woman, Dinah, to their secret Clocktower lair. The trio is complete. They are now the Birds of Prey, determined to battle crime in a New Gotham laced with bold new villains.

The Batman legend takes an unexpected turn when the Caped Crusader vanishes from the crime-ridden city of New Gotham and his legacy is taken over by a trio of beautiful and relentless heroines - the Birds of Prey. Barbara Gordon started out as Batman's protege, Batgirl, but an attack by The Joker left her confined to a wheelchair. Reinventing herself as Oracle, she takes under her wing Helena Kyle, the secret daughter of Batman and Catwoman, who quickly grows into the fierce and beautiful "Huntress", and Dinah, a teenage runaway who is drawn to the city by meta-human visions. With the help of the only honest cop in New Gotham, Detective Jesse Reese, the Birds of Prey fight their first battle against a mysterious madwoman who is bent on their destruction.